Immune Responses to Mycobacterial Antigens in the Gambian Population: Implications for Vaccines and Immunodiagnostic Test Design

Johan Vekemans; Martin O. C. Ota; Jackson Sillah; Katherine Fielding; Mark R. Alderson; Yasir A. W. Skeiky; Wilfried Dalemans; Keith P. W. J. McAdam; Christian Lienhardt; Arnaud Marchant

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Immune Responses to Mycobacterial Antigens in the Gambian Population: Implications for Vaccines and Immunodiagnostic Test Design

机译：冈比亚人群中对分枝杆菌抗原的免疫反应：对疫苗和免疫诊断测试设计的影响。

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Recombinant immunodominant mycobacterial antigens are needed for the development of new vaccines and immunodiagnostic tools for use against tuberculosis. Ubiquitous exposure to mycobacteria in tropical countries could influence vaccine-induced immunity and the specificity of tuberculosis immunodiagnosis. For this study conducted in The Gambia, cellular immune responses to recombinant mycobacterial antigens were characterized in Mycobacterium bovis BCG-vaccinated and nonvaccinated infants, adult community controls, household contacts, health care workers, and tuberculosis patients. Neonatal BCG vaccination induced gamma interferon (IFN-γ) responses to Mtb8.4, Mtb32-C, Mtb39A, Mtb9.9A, and Mtb32-N, but not CFP-10 (Mtb11) and α-crystallin (Mtb16). Exposure to Mycobacterium tuberculosis in household contacts and health care workers was associated with high responses to CFP-10 and α-crystallin. Generally, low IFN-γ responses were found in tuberculosis patients. These results suggest that Mtb8.4, Mtb32-C, Mtb39A, Mtb9.9A, and Mtb32-N may be used in a subunit vaccine to boost BCG-induced immunity. While CFP-10 and α-crystallin are promising candidates for the immunodiagnosis of M. tuberculosis infection or for vaccine use, disease-associated immunosuppression may prevent IFN-γ immunodiagnosis of more advanced tuberculosis.

机译：重组免疫优势分枝杆菌抗原是开发用于结核病的新疫苗和免疫诊断工具所必需的。在热带国家，无处不在的分枝杆菌接触会影响疫苗诱导的免疫和结核病免疫诊断的特异性。在冈比亚进行的这项研究中，接种了牛分枝杆菌和未接种牛的分枝杆菌牛，成年社区对照，家庭接触者，医护人员和肺结核患者对重组分枝杆菌抗原的细胞免疫反应进行了表征。新生儿BCG疫苗接种诱导了对Mtb8.4，Mtb32-C，Mtb39A，Mtb9.9A和Mtb32-N的伽马干扰素（IFN-γ）反应，但对CFP-10（Mtb11）和α-晶体蛋白（Mtb16）没有反应。家庭接触者和医护人员接触结核分枝杆菌与对CFP-10和α-结晶蛋白的高响应有关。通常，在结核病患者中发现低的IFN-γ反应。这些结果表明，Mtb8.4，Mtb32-C，Mtb39A，Mtb9.9A和Mtb32-N可用于亚单位疫苗中以增强BCG诱导的免疫力。 CFP-10和α-晶状体蛋白是 M免疫诊断的有希望的候选者。结核感染或用于疫苗，与疾病相关的免疫抑制可能会阻止IFN-γ对更晚期结核的免疫诊断。 展开▼

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《Infection and immunity》 |2004年第1期|共8页

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Johan Vekemans; Martin O. C. Ota; Jackson Sillah; Katherine Fielding; Mark R. Alderson; Yasir A. W. Skeiky; Wilfried Dalemans; Keith P. W. J. McAdam; Christian Lienhardt; Arnaud Marchant;
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中图分类医学免疫学;

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专利

1. Host immune responses to mycobacterial antigens and their implications for the development of a vaccine to control tuberculosis [J] . Yuk Jae-Min, Jo Eun-Kyeong Clinical and Experimental Vaccine Research . 2014,第2期

机译：宿主对分枝杆菌抗原的免疫反应及其对控制结核病疫苗开发的意义

2. Danger signals and nonself entity of tumor antigen are both required for eliciting effective immune responses against HER-2eu positive mammary carcinoma: Implications for vaccine design [J] . KmieciakM., MoralesJ.K., MoralesJ., Cancer immunology, immunotherapy : . 2008,第9期

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3. Danger signals and nonself entity of tumor antigen are both required for eliciting effective immune responses against HER-2eu positive mammary carcinoma: implications for vaccine design [J] . Maciej Kmieciak, Johanna K. Morales, Joshua Morales, Cancer Immunology, Immunotherapy . 2008,第9期

机译：引发针对HER-2 / neu阳性乳癌的有效免疫应答均需要危险信号和肿瘤抗原的非自身实体：对疫苗设计的影响

4. Protective effect of DNA vaccines encoding different mycobacterial antigens against Mycobacterium avium subspecies paratuberculosis in Sardinian lambs [C] . Mara L, Ortu S, Cappai P, International Colloquium on Paratuberculosis . 2007

机译：DNA疫苗对不同分枝杆菌抗原对撒丁岛羊草分枝杆菌亚种分枝杆菌的保护作用

5. Potentiation of the immune response with aluminum-containing adjuvants: I. Distribution of adsorbed antigen in mono-valent and combination vaccines; II. Role of antigen adsorption in antigen internalization by dendritic cells. [D] . Morefield, Garry Lee, Jr. 2003

机译：含铝佐剂增强免疫应答：I.单价和组合疫苗中吸附抗原的分布；二。抗原吸附在树突状细胞的抗原内在化中的作用。

6. Immune Responses to Mycobacterial Antigens in the Gambian Population: Implications for Vaccines and Immunodiagnostic Test Design [O] . Johan Vekemans, Martin O. C. Ota, Jackson Sillah, 2004

机译：冈比亚人口对分枝杆菌抗原的免疫反应：对疫苗和免疫诊断测试设计的影响。

7. Immune Responses to Mycobacterial Antigens in the Gambian Population: Implications for Vaccines and Immunodiagnostic Test Design [O] . Vekemans, Johan, Ota, Martin O. C., Sillah, Jackson, 2004

机译：冈比亚人群中对分枝杆菌抗原的免疫反应：对疫苗和免疫诊断测试设计的影响。

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5. 白俄罗斯结核感染者对新结核分枝杆菌抗原的模式识别和细胞免疫反应 [J] . 杨永良 ,潘新灵 . 国际免疫学杂志 . 2013,第001期

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2. 用于诱导抗结核分枝杆菌免疫反应的重组BCG肺结核疫苗 [P] . 中国专利： CN101939419A . 2011-01-05

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机译：分离的衣原体物种的Hmw蛋白，分离的核酸分子，重组表达载体，转化的宿主细胞，分离的重组蛋白或其片段或类似物，免疫原性组合物，抗原性组合物，在动物中产生免疫应答的过程，抗血清，抗体，诊断试剂，用于检测测试样品中的衣原体抗体，检测测试样品中的衣原体，预防，治疗或缓解需要此治疗的宿主中的衣原体相关疾病，并确定样品中是否存在编码hmw蛋白或其片段或类似物的核酸，诊断试剂盒以检测针对衣原体的抗体以及确定样品，疫苗组合物中是否存在编码hmw蛋白或其片段或类似物的核酸和药物成分

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Immune Responses to Mycobacterial Antigens in the Gambian Population: Implications for Vaccines and Immunodiagnostic Test Design

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