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Limited Role for Interleukin-18 in the Host Protection Response to Pulmonary Infection with Pseudomonas aeruginosa in Mice

机译:白细胞介素18在宿主保护小鼠对铜绿假单胞菌肺部感染的保护作用中的作用有限。

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摘要

We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
机译:我们报道在感染的肺中铜绿假单胞菌的清除,中性粒细胞的积累以及肿瘤坏死因子α和巨噬细胞炎性蛋白2的合成在白细胞介素18(IL-18)基因敲除或转基因小鼠与对照小鼠相比。我们的结果表明IL-18在针对 P的宿主防御中的作用有限。铜绿

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