首页> 外文期刊>Infection and immunity >Enteropathogenic Escherichia coliVirulence Genes Encoding Secreted Signalling Proteins Are Essential for Modulation of Caco-2 Cell Electrolyte Transport
【24h】

Enteropathogenic Escherichia coliVirulence Genes Encoding Secreted Signalling Proteins Are Essential for Modulation of Caco-2 Cell Electrolyte Transport

机译:肠致病性大肠杆菌编码分泌信号蛋白的毒力基因对于调节Caco-2细胞电解质运输至关重要

获取原文
           

摘要

The pathophysiology of enteropathogenic Escherichia coli (EPEC) diarrhea remains uncertain. In vitro, EPEC stimulates a rapid increase in short-circuit current (I sc) across Caco-2 cell monolayers coincident with intimate attaching and effacing (A/E) bacterial adhesion. This study has examined the roles of specific EPEC virulence proteins in this I scresponse. EPEC genes encoding EspA, EspB, and EspD, essential for signal transduction in host cells and A/E activity, were also required for modulation of Caco-2 electrolyte transport.
机译:肠致病性大肠埃希菌(EPEC)腹泻的病理生理学仍不确定。在体外,EPEC刺激跨整个Caco-2细胞单层的短路电流( I sc )快速增加,这与紧密附着和消失(A / E)细菌粘附相吻合。这项研究检查了特定的EPEC毒力蛋白在此 I sc 响应中的作用。编码EcaA,EspB和EspD的EPEC基因对于宿主细胞中的信号转导和A / E活性至关重要,也是调制Caco-2电解质转运所必需的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号