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首页> 外文期刊>Infection and immunity >Neutralizing Antibodies to Adenylate Cyclase Toxin Promote Phagocytosis of Bordetella pertussis by Human Neutrophils
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Neutralizing Antibodies to Adenylate Cyclase Toxin Promote Phagocytosis of Bordetella pertussis by Human Neutrophils

机译：腺苷酸环化酶毒素的中和抗体促进人嗜中性粒细胞吞噬百日咳博德特氏菌的吞噬作用。

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A previous study showed that opsonization with human immune serum could either promote or antagonize phagocytosis of Bordetella pertussis by human neutrophils depending on whether the bacteria expressed adenylate cyclase toxin. Opsonization of the wild-type strain inhibited phagocytosis relative to unopsonized controls. In contrast, mutants lacking adenylate cyclase toxin were efficiently phagocytosed when opsonized with human immune serum. In this study, we examined opsonization in the presence or absence of monoclonal antibodies to adenylate cyclase toxin. Addition of neutralizing monoclonal antibodies to adenylate cyclase toxin converted a serum that previously inhibited both attachment and phagocytosis of the wild-type strain to one that increased both attachment and phagocytosis compared to the no-serum control. Monoclonal antibodies that recognize the adenylate cyclase toxin but fail to neutralize activity were without effect. These results suggest that adenylate cyclase toxin inhibits both Fc receptor-mediated attachment and phagocytosis of B. pertussis by neutrophils.
机译：先前的研究表明，用人免疫血清调理可促进或拮抗人中性粒细胞对百日咳杆菌的吞噬作用，这取决于细菌是否表达腺苷酸环化酶毒素。相对于未调理的对照，野生型菌株的调理作用抑制吞噬作用。相反，与人免疫血清调理后，缺乏腺苷酸环化酶毒素的突变体被有效吞噬。在这项研究中，我们检查了是否存在针对腺苷酸环化酶毒素的单克隆抗体的调理作用。与无血清对照相比，向腺苷酸环化酶毒素添加中和性单克隆抗体将先前抑制野生型菌株的附着和吞噬作用的血清转变为既增加附着又吞噬作用的血清。识别腺苷酸环化酶毒素但无法中和活性的单克隆抗体无效。这些结果表明腺苷酸环化酶毒素同时抑制Fc受体介导的附着和 B的吞噬作用。中性粒细胞引起的百日咳。

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