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Decreased Antitoxic Activities among Children with Clinical Episodes of Malaria

机译：疟疾临床发作儿童的抗毒活性降低

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Healthy Gambian children, children with clinical Plasmodium falciparum malaria, and children with asymptomatic P. falciparum infections were studied to investigate whether antitoxic activities may contribute to protection against malarial symptoms. Markers of inflammatory reactions, soluble tumor necrosis factor receptor I, and C-reactive protein were found in high concentrations in children with symptomatic P. falciparummalaria compared with levels in children with asymptomatic P. falciparum infections or in healthy children, indicating that inflammatory reactions are induced only in children with clinical symptoms. Concentrations of soluble tumor necrosis factor receptor I and C-reactive protein were associated with levels of parasitemia. We detected antitoxic activities in sera as measured by their capacity to block toxin-induced Limulus amoebocyte lysate (LAL) activation. Symptomatic children had decreased capacity to block induction of LAL activation by P. falciparum exoantigen. The decreased blocking activity was restored in the following dry season, when the children had no clinical malaria. Symptomatic children also had the highest immunoglobulin G (IgG) reactivities to conservedP. falciparum erythrocyte membrane protein 1 and “Pfalhesin” (band #3) peptides, indicating that such IgG antibodies are stimulated by acute disease but are lost rapidly after the disease episode. Half of the children with symptomatic infections had low levels of haptoglobin, suggesting that these children had chronicP. falciparum infections which may have caused symptoms previously. Only a few of the children with asymptomatic P. falciparum infections had high parasite counts, and antitoxic immunity in the absence of antiparasite immunity appears to be rare among children in this community.
机译：健康的冈比亚儿童，患有临床恶性疟原虫的儿童和无症状 P的儿童。研究了恶性疟原虫感染，以研究抗毒活性是否有助于预防疟疾症状。在有症状的 P患儿中发现高浓度的炎症反应，可溶性肿瘤坏死因子受体I和C反应蛋白。恶性疟原虫与无症状 P儿童的水平比较。恶性疟原虫感染或健康儿童，表明炎症反应仅在具有临床症状的儿童中诱发。可溶性肿瘤坏死因子受体I和C反应蛋白的浓度与寄生虫血症的水平有关。我们通过检测其阻断毒素诱导的 Li 变形细胞裂解液（LAL）活化的能力来检测其血清中的抗毒活性。有症状的儿童阻止 P诱导LAL激活的能力降低。恶性肿瘤外抗原。当儿童没有临床疟疾时，在接下来的旱季恢复了降低的阻断活性。有症状的儿童对保守的P的免疫球蛋白G（IgG）反应性也最高。恶性疟原虫红细胞膜蛋白1和“ Pfalhesin”（3号带）肽，表明此类IgG抗体受急性疾病刺激，但在疾病发作后迅速消失。有症状感染的儿童中有一半的触珠蛋白水平较低，这表明这些儿童患有慢性 P。以前可能引起症状的恶性疟原虫感染。只有少数无症状 P的儿童。恶性疟原虫感染的寄生虫数量很高，在这个社区的儿童中，缺乏抗寄生虫免疫力的抗毒性免疫似乎很少。

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