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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.
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Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.

机译：简短报告：在乌干达市区的一个城市队列中，靠近蚊子繁殖地点是临床疟疾发作的危险因素。

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摘要

The impact of geography on incidence of clinical episodes of malaria was investigated in a cohort of children enrolled in a longitudinal clinical trial of antimalarial therapy in Kampala, Uganda. Participant households and the boundaries of local swamps and streams were mapped and incidence of clinical malaria episodes was measured prospectively using passive surveillance during one year of follow-up. Of 316 cohort participants, 305 from 219 households were followed for at least six weeks and were included in the analysis. Incidence of clinical malaria was highly variable, with no episodes occurring in 131 participants, and 367 new episodes of malaria diagnosed in the remaining 174 children. A gradient in incidence of clinical episodes of malaria was observed with distance of residence from a swamp (0.41 episodes per person year for residence > 100 meters from a swamp increasing to 2.22 episodes per person year for residence within a swamp), or a stream (0.61 episodes per person year for residence > or= 500 meters from a stream versus 1.76 episodes per person year for residence <500 meters from a stream). Multivariate analysis showed that distances of residence from a swamp or from a stream were independent predictors of malaria incidence, controlling for age, use of preventative measures, and primary source of water. Distance from a swamp was the strongest predictor, with an incidence rate ratio of 4.3 (95% confidence interval = 2.6-6.9, P < 0.001) between residence within a swamp and >100 meters from a swamp. In this urban setting, incidence of clinical episodes of malaria was strongly associated with proximity of residence to potential mosquito breeding sites.
机译：在乌干达坎帕拉进行的一项抗疟疾治疗纵向临床试验的一组儿童中，研究了地理因素对疟疾临床发作率的影响。在随访的一年中，采用被动监测的方法，对参与调查的家庭以及当地沼泽和河流的边界进行了测绘，并对临床疟疾发作的发生率进行了前瞻性测量。在316个队列参与者中，对219个家庭中的305个家庭进行了至少六个星期的随访，并将其纳入分析。临床疟疾的发病率变化很大，131名参与者中没有发作，其余174名儿童中诊断出367次新的疟疾发作。观察到疟疾临床发作的发生率与沼泽的居住距离呈梯度关系（居住地每人每年0.41次发作>沼泽地100米以内居民每人每年增加2.22次发作）或溪流（距离溪流大于或等于500米的居民，每人年0.61集，而距离溪流小于或等于500米的居民，每人年1.76集）。多变量分析表明，从沼泽或溪流到居民的距离是疟疾发病率的独立预测因子，可控制年龄，使用预防措施和主要水源。与沼泽的距离是最强的预测指标，在沼泽中的居住地与距离沼泽> 100米之间的发生率比率为4.3（95％置信区间= 2.6-6.9，P <0.001）。在这个城市环境中，疟疾临床发作的发生与居住地与潜在蚊子繁殖地点的接近程度密切相关。

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