Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites.

L Rénia; D Xia; D Samols; V Nussenzweig

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Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites.

机译：表达C反应蛋白的转基因小鼠易受约氏疟原虫子孢子感染。

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Human and rat C-reactive proteins, major acute-phase reactants, bind to sporozoites and inhibit their in vitro development in hepatocytes (A. Nussler, S. Pied, M. Pontet, F. Miltgen, L. Renia, M. Gentilini, and D. Mazier, Exp. Parasitol. 72:1-7, 1991, and S. Pied, A. Nussler, M. Pontet, F. Miltgen, H. Matile, P.-H. Lambert, and D. Mazier, Infect. Immun. 57:278-282, 1989). We show here that rabbit C-reactive protein has identical properties. Nevertheless, infection by Plasmodium yoelii sporozoites was not prevented in transgenic mice engineered to express rabbit C-reactive protein following induction of gluconeogenesis.

机译：人和大鼠C反应蛋白是主要的急性期反应物，它们与子孢子结合并抑制其在肝细胞中的体外发育（A.Nussler，S.Pied，M.Pontet，F.Miltgen，L.Renia，M.Gentilini， 1991年，D。Mazier，Exp。Parasitol。72：1-7; S。Pied，A。Nusler，M。Pontet，F。Miltgen，H。Matile，P.-H。Lambert和D. Mazier， Infect.Immun.57：278-282，1989）。我们在这里表明，兔C反应蛋白具有相同的属性。然而，在诱导糖原异生后经工程改造表达兔C反应蛋白的转基因小鼠中，不能阻止约氏疟原虫子孢子的感染。

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《Infection and immunity》 |1993年第1期|共2页
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L Rénia; D Xia; D Samols; V Nussenzweig;
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中图分类医学免疫学;
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1. Monoclonal antibodies of three different immunoglobulin G isotypes produced by immunization with a synthetic peptide or native protein protect mice against challenge with Plasmodium yoelii sporozoites. [J] . M Ak, J H Bower, S L Hoffman, Infection and immunity . 1993,第6期

机译：通过合成肽或天然蛋白免疫产生的三种不同免疫球蛋白G同种型的单克隆抗体可保护小鼠免受约氏疟原虫子孢子的攻击。
2. Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice. [J] . Miyata T., Harakuni T., Taira T., Vaccine . 2012,第5期

机译：通过酵母中表达的霍乱毒素B亚基糖蛋白的寡糖部分融合的约氏疟原虫的裂殖子表面蛋白1诱导了对小鼠致命疟疾感染的保护性免疫。
3. CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1(19)) formulated in oil-bas [J] . Hirunpetcharat C, Wipasa J, Sakkhachornphop S, Vaccine . 2003,第21a22期

机译：CpG寡脱氧核苷酸增强了用酵母表达的油基巴斯夫疟原虫裂殖子表面蛋白-1（MSP1（19））的酵母表达的19 kDa羧基末端片段进行肠胃外免疫的小鼠的抗血液阶段疟疾感染的免疫力。
4. Heterologous encapsidation of potyviruses in mixed infections and in transgenic Nicotiana benthamiana expressing the coat protein gene of plum pox potyvirus (PPV) [C] . Edgar Maiss, D.-E. Lesemann, R. Koenig Key biosafety aspects of genetically modified organisms . 1995

机译：在混合感染和表达李子痘病毒（PPV）外壳蛋白基因的转基因烟草（Nicotiana benthamiana）中，马铃薯病毒的异源衣壳化
5. C-reactive protein: A study of its functional domains using transgenic mice. [D] . Black, Steven Gregory. 2005

机译：C反应蛋白：使用转基因小鼠对其功能域的研究。
6. Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites. [O] . L Rénia, D Xia, D Samols, 1993

机译：表达C反应蛋白的转基因小鼠易受约氏疟原虫子孢子感染。
7. Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites [O] . L Rénia, D Xia, D Samols, 1993

机译：表达C-反应蛋白的转基因小鼠易于用疟原虫感染yoelii孢子菌感染
8. Monoclonal Antibodies of Three Different Immunoglobulin G Isotypes Produced byImmunization with a Synthetic Peptide or Native Protein Protect Mice against Challenge with Plasmodium Yoelii Sporozoites. (Reannouncement with New Availability Information) [R] . Mucide, A. K., Bower, J. H., Hoffman, S. L., 1993

机译：通过用合成肽或天然蛋白质免疫小鼠产生的三种不同免疫球蛋白G同种型的单克隆抗体保护小鼠免受恶性疟原虫子孢子的攻击。（重新公布新的可用性信息）

Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites.

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