FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease.

Y Ge; N W Charon

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FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease.

机译：FlaA，一种假定的鞭毛外鞘蛋白，不是与莱姆病相关的免疫优势抗原。

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FlaA was recently found to be associated with flagellar filaments of Borrelia burgdorferi. We tested whether antibodies to this protein are a good indicator of infection, as antibodies to FlaA proteins in other spirochetal infections show an increase in titer. Although overproduction of intact FlaA was highly toxic to Escherichia coli, truncated proteins which lacked the N-terminal signal sequence could be successfully overexpressed. Immunoblotting with sera from mammalian hosts infected with B. burgdorferi indicated that FlaA is not an immunodominant antigen in Lyme disease. However, sera from two patients reacted with both recombinant and native FlaA protein, suggesting that B. burgdorferi FlaA was antigenic and expressed in vivo.

机译：最近发现FlaA与伯氏疏螺旋体的鞭毛细丝有关。我们测试了针对这种蛋白质的抗体是否是感染的良好指标，因为在其他螺旋体感染中针对FlaA蛋白质的抗体显示滴度增加。尽管过量生产的完整FlaA对大肠杆菌具有很高的毒性，但缺少N末端信号序列的截短蛋白可以成功表达。来自感染伯氏疏螺旋体的哺乳动物宿主的血清免疫印迹表明，FlaA不是莱姆病的免疫优势抗原。但是，两名患者的血清与重组和天然FlaA蛋白都发生了反应，这表明B. burgdorferi FlaA具有抗原性并在体内表达。

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《Infection and immunity》 |1997年第7期|共4页
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Y Ge; N W Charon;
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中图分类医学免疫学;
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1. FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease. [J] . Y Ge, N W Charon Infection and immunity . 1997,第7期

机译：FlaA，一种假定的鞭毛外鞘蛋白，不是与莱姆病相关的免疫优势抗原。
2. The Spirochete FlaA Periplasmic Flagellar Sheath Protein Impacts Flagellar Helicity [J] . Chunhao Li, Linda Corum, David Morgan, Journal of bacteriology . 2000,第23期

机译：Spirochete FlaA周质鞭毛鞘蛋白影响鞭毛螺旋度
3. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium (see comments) (published erratum appears in N Engl J Med 1998 Aug 20; [J] . Sigal LH, Zahradnik JM, Lavin P, The New England journal of medicine . 1998,第4期

机译：一种由重组伯氏疏螺旋体外表面蛋白A预防莱姆病的疫苗。重组外表面蛋白A莱姆病疫苗研究联合会（请参阅注释）（勘误表发表于1998年8月20日的N Engl J Med;
4. Quantitation of Three Outer Surface Proteins From The Lyme Disease Spirochete, Borrelia Burgdorferi By Nanoparticle Capture / Multiple Reaction Monitoring-Mass Spectrometry. [C] . Paul Russo, Davide Tamburro, Claudia Fredolini, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：荔枝疾病三种外表面蛋白的定量，培斯基捕获/多反应监测质谱法通过培养基菌螺旋体，Borrelia Burgdorferi。
5. Examination of putative outer membrane proteins in Moraxella catarrhalis: A genome mining approach for the identification of potential vaccine antigens. [D] . Ruckdeschel, Elizabeth Anne. 2009

机译：卡他莫拉菌中推定的外膜蛋白的检查：一种用于鉴定潜在疫苗抗原的基因组挖掘方法。
6. FlaA a putative flagellar outer sheath protein is not an immunodominant antigen associated with Lyme disease. [O] . Y Ge, N W Charon 1997

机译：FlaA一种假定的鞭毛外鞘蛋白不是与莱姆病相关的免疫优势抗原。
7. FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease [O] . Y Ge, N W Charon 1997

机译：推定鞭毛外鞘蛋白的FLAA不是与莱姆病相关的免疫模数抗原

FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease.

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