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首页> 外文期刊>Infection and immunity >Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity
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Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity

机译：婴儿口腔中血红球菌的自然史：离散感染窗的证据

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The heterogeneous group of oral bacteria within the sanguinis (sanguis) streptococci comprise members of the indigenous biota of the human oral cavity. While the association of Streptococcus sanguinis with bacterial endocarditis is well described in the literature, S. sanguinis is thought to play a benign, if not a beneficial, role in the oral cavity. Little is known, however, about the natural history of S. sanguinis and its specific relationship with other oral bacteria. As part of a longitudinal study concerning the transmission and acquisition of oral bacteria within mother-infant pairs, we examined the initial acquisition of S. sanguinis and described its colonization relative to tooth emergence and its proportions in plaque and saliva as a function of other biological events, including subsequent colonization with mutans streptococci. A second cohort of infants was recruited to define the taxonomic affiliation of S. sanguinis. We found that the colonization of the S. sanguinis occurs during a discrete “window of infectivity” at a median age of 9 months in the infants. Its colonization is tooth dependent and correlated to the time of tooth emergence; its proportions in saliva increase as new teeth emerge. In addition, early colonization of S. sanguinis and its elevated levels in the oral cavity were correlated to a significant delay in the colonization of mutans streptococci. Underpinning this apparent antagonism between S. sanguinis and mutans streptococci is the observation that after mutans streptococci colonize the infant, the levels of S. sanguinis decrease. Children who do not harbor detectable levels of mutans streptococci have significantly higher levels of S. sanguinis in their saliva than do children colonized with mutans streptococci. Collectively, these findings suggest that the colonization of S. sanguinis may influence the subsequent colonization of mutans streptococci, and this in turn may suggest several ecological approaches toward controlling dental caries.
机译：Sanguinis（sanguis）链球菌中的口腔细菌异质性组包括人类口腔原生生物群的成员。虽然在文献中很好地描述了血红链球菌与细菌性心内膜炎的关系，但是血红链球菌在口腔中起着良性的作用，即使不是有益的。然而，关于血红链球菌的自然史及其与其他口腔细菌的特殊关系知之甚少。作为关于母婴对中口腔细菌传播和获取的纵向研究的一部分，我们检查了血红链球菌的最初获取情况，并描述了其相对于牙齿出生的定植及其在牙菌斑和唾液中的比例与其他生物学功能的关系。事件，包括随后的变形链球菌定植。招募了第二批婴儿，以定义血红链球菌的分类学隶属关系。我们发现，血色链球菌的定殖发生在婴儿的中位年龄为9个月的离散“传染性窗口”期间。它的定植与牙齿有关，并与牙齿的出现时间有关。随着新牙齿的出现，其在唾液中的比例增加。此外，血红链球菌的早期定植及其在口腔中的升高水平与变形链球菌定植的显着延迟有关。血链球菌与变形链球菌之间明显的拮抗作用是观察到，在变形链球菌定植于婴儿后，血链球菌的水平会降低。未携带可检测到的变形链球菌水平的儿童其唾液中的血红链球菌水平明显高于被变形链球菌感染的儿童。总的来说，这些发现表明血红链球菌的定殖可能影响随后变形链球菌的定殖，这反过来可能暗示了几种控制龋齿的生态学方法。

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