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首页> 外文期刊>Infection and immunity >Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization
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Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

机译：通过局部或中央（共同）粘膜免疫产生女性生殖道抗体反应

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Genital antibody responses were compared in female mice immunized intravaginally (i.vag.) or intranasally (i.n.) with a bacterial protein antigen (AgI/II of Streptococcus mutans) coupled to the B subunit of cholera toxin. Serum and salivary antibodies were also evaluated as measures of disseminated mucosal and systemic responses. Although i.vag. immunization induced local vaginal immunoglobulin A (IgA) and IgG antibody responses, these were not disseminated to a remote secretion, the saliva, and only modest levels of serum antibodies were generated. In contrast, i.n. immunization was substantially more effective at inducing IgA and IgG antibody responses in the genital tract and in the circulation, as well as at inducing IgA antibodies in the saliva. Moreover, mucosal and systemic antibodies induced by i.n. immunization persisted for at least 12 months. Analysis of the molecular form of genital IgA indicated that the majority of both total IgA and specific IgA antibody was polymeric, and likely derived from the common mucosal immune system.
机译：比较了在阴道内（i.vag。）或鼻内（i.n.）用与霍乱毒素B亚基偶联的细菌蛋白抗原（变异链球菌（Streptococcus mutans）的AgI / II）免疫的雌性小鼠的生殖器抗体反应。还评估了血清和唾液抗体，作为弥散性粘膜和全身反应的量度。虽然我。免疫诱导的局部阴道免疫球蛋白A（IgA）和IgG抗体反应，这些没有散布到远端分泌物，唾液中，仅产生了中等水平的血清抗体。相反，i.n。免疫在诱导生殖道和循环中的IgA和IgG抗体反应以及诱导唾液中的IgA抗体方面更为有效。此外，由i.n.诱导的粘膜和全身抗体。免疫持续至少12个月。生殖器IgA分子形式的分析表明，总IgA和特异性IgA抗体中的大多数都是聚合性的，并且很可能来源于常见的粘膜免疫系统。

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