...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Meningococcal Outer Membrane Protein NhhA Is Essential for Colonization and Disease by Preventing Phagocytosis and Complement Attack
【24h】

Meningococcal Outer Membrane Protein NhhA Is Essential for Colonization and Disease by Preventing Phagocytosis and Complement Attack

机译：脑膜炎球菌外膜蛋白NhhA通过预防吞噬作用和补体攻击对殖民化和疾病至关重要

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neisseria meningitidis is a leading cause of meningitis and septicemia worldwide, with a rapid onset of disease and a high morbidity and mortality. NhhA is a meningococcal outer membrane protein included in the family of trimeric autotransporter adhesins. The protein binds to the extracellular matrix proteins heparan sulfate and laminin and facilitates attachment to host epithelial cells. In this study, we show that NhhA is essential for bacterial colonization of the nasopharyngeal mucosa in a murine model of meningococcal disease. Successful colonization depends on bacterial attachment but also to the capacity to overcome innate host immune responses. We found that NhhA protected bacteria from phagocytosis, which is important for the mucosal survival of bacteria. In addition, NhhA mediated extensive serum resistance that increased bacterial survival in blood and promoted lethal sepsis. The presence of NhhA protected bacteria from complement-mediated killing by preventing the deposition of the membrane attack complex. Taken together, the results of this work reveal that NhhA inhibits phagocytosis and protects bacteria against complement-mediated killing, which enhances both nasal colonization and the development of sepsis in vivo.
机译：脑膜炎奈瑟氏球菌（Neisseria meningitidis）是全世界脑膜炎和败血病的主要原因，发病迅速，发病率和死亡率高。 NhhA是三聚体自转运粘附素家族中的一种脑膜炎球菌外膜蛋白。该蛋白与细胞外基质蛋白硫酸乙酰肝素和层粘连蛋白结合，并促进与宿主上皮细胞的附着。在这项研究中，我们显示NhhA对于在脑膜炎球菌疾病的小鼠模型中鼻咽粘膜的细菌定植至关重要。成功的定殖取决于细菌的附着，但也取决于克服先天宿主免疫反应的能力。我们发现NhhA保护细菌免受吞噬作用，这对于细菌的黏膜存活很重要。此外，NhhA介导了广泛的血清抗药性，增加了血液中细菌的存活率并促进了致命性败血症。 NhhA的存在通过阻止膜攻击复合物的沉积来保护细菌免受补体介导的杀伤。两者合计，这项工作的结果表明NhhA抑制吞噬作用并保护细菌免受补体介导的杀伤，从而增强了鼻部定植和体内败血症的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号