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首页> 外文期刊>Infection and immunity >Prolonged Impact of Antibiotics on Intestinal Microbial Ecology and Susceptibility to Enteric Salmonella Infection
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Prolonged Impact of Antibiotics on Intestinal Microbial Ecology and Susceptibility to Enteric Salmonella Infection

机译：抗生素对肠道微生物生态学和肠道沙门氏菌感染敏感性的长期影响

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The impact of antibiotics on the host's protective microbiota and the resulting increased susceptibility to mucosal infection are poorly understood. In this study, antibiotic regimens commonly applied to murine enteritis models are used to examine the impact of antibiotics on the intestinal microbiota, the time course of recovery of the biota, and the resulting susceptibility to enteric Salmonella infection. Molecular analysis of the microbiota showed that antibiotic treatment has an impact on the colonization of the murine gut that is site and antibiotic dependent. While combinations of antibiotics were able to eliminate culturable bacteria, none of the antibiotic treatments were effective at sterilizing the intestinal tract. Recovery of total bacterial numbers occurs within 1 week after antibiotic withdrawal, but alterations in specific bacterial groups persist for several weeks. Increased Salmonella translocation associated with antibiotic pretreatment corrects rapidly in association with the recovery of the most dominant bacterial group, which parallels the recovery of total bacterial numbers. However, susceptibility to intestinal colonization and mucosal inflammation persists when mice are infected several weeks after withdrawal of antibiotics, correlating with subtle alterations in the intestinal microbiome involving alterations of specific bacterial groups. These results show that the colonizing microbiotas are integral to mucosal host protection, that specific features of the microbiome impact different aspects of enteric Salmonella pathogenesis, and that antibiotics can have prolonged deleterious effects on intestinal colonization resistance.
机译：人们对抗生素对宿主保护性微生物群的影响以及由此引起的对粘膜感染的敏感性增加的了解很少。在这项研究中，通常用于鼠类肠炎模型的抗生素方案用于检查抗生素对肠道菌群的影响，菌群恢复的时间过程以及由此产生的对肠沙门氏菌感染的敏感性。微生物群的分子分析表明，抗生素治疗对定点和抗生素依赖性的鼠肠道定殖有影响。虽然抗生素的组合能够消除可培养细菌，但是没有一种抗生素治疗能有效地对肠道消毒。总细菌数的恢复发生在抗生素停用后1周内，但特定细菌组的改变持续了数周。与抗生素预处理有关的沙门氏菌易位增加与最主要细菌组的恢复相关，可迅速纠正，这与总细菌数的恢复平行。但是，在撤回抗生素几周后感染小鼠时，对肠道菌落和粘膜炎症的敏感性仍然存在，这与肠道微生物组的细微变化有关，涉及特定细菌群的变化。这些结果表明，定殖微生物群是粘膜宿主保护不可或缺的部分，微生物组的特定特征会影响肠沙门氏菌发病机理的不同方面，并且抗生素对肠道定殖耐药性可能具有长期有害作用。

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