MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

Charles A. Scanga; Andre Bafica; Carl G. Feng; Allen W. Cheever; Sara Hieny; Alan Sher

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MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

机译：MyD88缺陷小鼠显示出对部分分枝的Th1细胞因子和一氧化氮合酶2表达受损相关的结核分枝杆菌耐药性的深刻丧失。

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Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88?/? mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88?/? mice failed to control mycobacterial replication and rapidly succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals. These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs.

机译：结核分枝杆菌对几种Toll样受体（TLR）具有激动剂，但是具有单个TLR缺失的小鼠对急性肺结核具有抗性。使用MyD88 ？/？小鼠检查TLR是否在针对气源性 M的保护中发挥任何作用。结核HemR37感染。 MyD88 ？/？小鼠未能控制分枝杆菌的复制并迅速死亡。此外，基因敲除动物中白介素12，肿瘤坏死因子α，γ干扰素和一氧化氮合酶2的表达明显降低。这些结果表明对 M的抗性。结核病必须依靠尚未确定的TLR或TLR组合介导的MyD88依赖性信号。 展开▼

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《Infection and immunity》 |2004年第4期|共5页

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Charles A. Scanga; Andre Bafica; Carl G. Feng; Allen W. Cheever; Sara Hieny; Alan Sher;
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中图分类医学免疫学;

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1. Inducible Nitric Oxide Synthase-Deficient Mice Develop Enhanced Type 1 Cytokine-Associated Cellular and Humoral Immune Responses after Vaccination with AttenuatedSchistosoma mansoni Cercariae but Display Partially Reduced Resistance [J] . Stephanie L. James, Allen W. Cheever, Patricia Caspar, Infection and immunity . 1998,第8期

机译：诱导型一氧化氮合酶缺陷小鼠在接种减毒的曼氏血吸虫尾rc后接种疫苗，可增强1型细胞因子相关的细胞和体液免疫反应，但显示部分降低的抵抗力

2. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. [J] . Ghadimi D, de Vrese M, Heller KJ, International immunopharmacology . 2010,第6期

机译：乳酸菌通过响应结核分枝杆菌抗原增加Th1自噬促进细胞因子（IFN-γ）和一氧化氮（NO）的水平并降低Th2自噬抑制细胞因子（IL-4和IL-13）来增强单核吞噬细胞的自噬能力。。

3. Th1 Cytokines Facilitate CD8-T-Cell-Mediated Early Resistance to Infection with Mycobacterium tuberculosis in Old Mice [J] . Bridget Vesosky, David K. Flaherty, Joanne Turner Infection and immunity . 2006,第6期

机译：Th1细胞因子促进CD8-T细胞介导的早期小鼠结核分枝杆菌感染的抗性。

4. Antisense RNA to Inducible Nitric Oxide Synthase Reduces Cytokine-Mediated Brain Endothelial Cell Death [C] . DING-I YANG, SHAWEI CHEN, UTHAYASHANKER R. EZEKIEL, Asian Society for Mitochondrial Research and Medicine . 2005

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5. The human neuronal nitric oxide synthase gene: RNA biology guiding expressional regulation. [D] . Newton, Derek Colin. 2004

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6. MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression [O] . Charles A. Scanga, Andre Bafica, Carl G. Feng, 2004

机译：MyD88缺陷小鼠显示出与部分受损的Th1细胞因子和一氧化氮合酶2表达相关的对结核分枝杆菌的抵抗力丧失。

7. MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression [O] . Scanga, Charles A., Bafica, Andre, Feng, Carl G., 2004

机译：MyD88缺陷小鼠显示出与部分受损的Th1细胞因子和一氧化氮合酶2表达相关的对结核分枝杆菌的抵抗力丧失。

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MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

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