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首页> 外文期刊>Infection and immunity >Distinct Th1- and Th2-Type Prenatal Cytokine Responses to Plasmodium falciparum Erythrocyte Invasion Ligands
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Distinct Th1- and Th2-Type Prenatal Cytokine Responses to Plasmodium falciparum Erythrocyte Invasion Ligands

机译：不同的Th1和Th2型产前细胞因子对恶性疟原虫红细胞入侵配体的反应

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Prenatal immunity to Plasmodium falciparum merozoite proteins involved in erythrocyte invasion may contribute to the partial protection against malaria that is acquired during infancy in areas of stable malaria transmission. We examined newborn and maternal cytokine and antibody responses to merozoite surface protein-1 (MSP-1), ribosomal phosphoprotein P0 (PfP0), and region II of erythrocyte binding antigen-175 (EBA-175) in infant-mother pairs in Kenya. Overall, 82 of 167 (50%), 106 of 176 (60%), and 38 of 84 (45%) cord blood lymphocytes (CBL) from newborns produced one or more cytokines in response to MSP-1, PfP0, and EBA-175, respectively. Newborns of primigravid and/or malaria-infected women were more likely to have antigen-responsive CBL than were newborns of multigravid and/or uninfected women at delivery. Newborn cytokine responses did not match those of their mothers and fell into three distinct categories, Th1 (21 of 55 CBL donors produced only gamma interferon and/or interleukin 2 [IL-2]), Th2 (21 of 55 produced only IL-5 and/or IL-13), and mixed Th1/Th2 (13 of 55). Newborns produced more IL-10 than adults. High and low levels of cord blood IL-12 p70 production induced by anti-CD40 activation were associated with malaria-specific Th1 and Th2 responses, respectively. Antigen-responsive CBL in some newborns were detected only after depletion of IL-10-secreting CD8 cells with enrichment for CD4 cells. These data indicate that prenatal sensitization to blood-stage Plasmodium falciparum occurs frequently in areas where malaria is holoendemic. Modulation of this immunity, possibly by maternal parity and malaria, may affect the acquisition of protective immunity against malaria during infancy.
机译：产前对参与红细胞侵袭的恶性疟原虫裂殖子蛋白的免疫力可能有助于部分预防疟疾，这是在婴儿期稳定传播疟疾的地区获得的。我们在肯尼亚的婴儿对中检查了新生儿和母亲的细胞因子以及对裂殖子表面蛋白-1（MSP-1），核糖体磷蛋白P0（PfP0）和红细胞结合抗原175（EBA-175）的II区的反应。总体而言，新生儿的167例脐血淋巴细胞（CBL）中有82例（50％），176例中有106例（60％）和38例中有38例（45％）（45％）产生了一种或多种细胞因子，以响应MSP-1，PfP0和EBA分别为-175。与多重和/或未感染妇女的新生儿分娩相比，初生和/或疟疾感染妇女的新生儿更有可能发生抗原反应性CBL。新生儿细胞因子的反应与母亲的反应不匹配，分为三个不同的类别：Th1（55个CBL供体中的21个仅产生γ干扰素和/或白介素2 [IL-2]），Th2（55个中的21个仅产生IL-5）和/或IL-13），以及混合的Th1 / Th2（55个中的13个）。新生儿比成人产生更多的IL-10。抗CD40激活诱导的脐血IL-12 p70产生的高和低水平分别与疟疾特异性Th1和Th2反应有关。仅在分泌IL-10-分泌的CD8细胞耗竭CD4细胞后，才检测到某些新生儿的抗原反应性CBL。这些数据表明，在疟疾是全血统的地区，产前对恶性疟原虫血液的致敏作用经常发生。这种免疫力的调节，可能是由产妇的均等和疟疾引起的，可能会影响婴儿期获得的针对疟疾的保护性免疫力。

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