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Nasal Colonization with Streptococcus pneumoniae Includes Subpopulations of Surface and Invasive Pneumococci

机译：肺炎链球菌在鼻部定植包括表面和侵袭性肺炎球菌亚群

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We demonstrated that during colonization with Streptococcus pneumoniae the nasal mucosal tissues of mice support two populations of pneumococci. Transparent-phase pneumococci can be readily washed from the outer surface, while a second population composed of primarily opaque-phase pneumococci is released only by homogenization of the nasal tissue. The fact that the opaque phase has previously been associated with invasion and the fact that opaque-phase pneumococci were released by homogenization of previously washed nasal tissue suggest that the opaque-phase pneumococci may have invaded the nasal tissue. Consistent with this hypothesis was our observation that there was inflammation in portions of the nasal mucosa of the colonized mice but not in the mucosa of noncolonized mice, but this observation did not prove the hypothesis. If the opaque-phase pneumococci released from the nasal tissue were from within the tissue and/or if resistance of the opaque-phase subpopulation to antibody, complement, and phagocytes is essential for long-term carriage, it seems likely that the virulence factors of S. pneumoniae that are necessary for killing humans exist to facilitate carriage. Although this speculation is unproven, the observation that there are separate populations of pneumococci during colonization may help guide future attempts to understand the biology of nasal colonization by this pathogen.
机译：我们证明了在肺炎链球菌定植期间，小鼠的鼻粘膜组织支持两个肺炎球菌种群。透明相肺炎球菌可以很容易地从外表面洗掉，而主要由不透明相肺炎球菌组成的第二种群仅通过鼻组织的均质化而释放。不透明相以前与侵袭有关的事实以及不透明相肺炎球菌通过均质化先前洗涤过的鼻组织而释放的事实表明，不透明相肺炎球菌可能已经侵入了鼻组织。与该假设一致的是我们的观察结果，即定殖小鼠的鼻粘膜部分存在炎症，而非定殖小鼠的鼻粘膜中没有炎症，但是该观察结果不能证明该假说。如果从鼻腔组织中释放出的不透明相肺炎球菌来自组织内部和/或如果不透明相亚群对抗体，补体和吞噬细胞的抵抗力对于长期运输至关重要，那么看来可能是由于 S。杀死人类所必需的肺炎存在以利于运输。尽管这种推测尚未得到证实，但观察到在定植过程中存在单独的肺炎球菌种群可能有助于指导未来尝试，以了解这种病原体对鼻定殖的生物学作用。

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