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Streptococcus pneumoniae Biofilm Formation Is Strain Dependent, Multifactorial, and Associated with Reduced Invasiveness and Immunoreactivity during Colonization.

机译:肺炎链球菌生物膜形成是菌株依赖性,多因素,并且与定殖期间的侵入性和免疫反应性降低相关。

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摘要

Biofilms are thought of play an important role during colonization of the nasopharynx by Strptococcus pneumoniae, yet how they form in vivo and the determinants responsible remain unknown. Using scanning electron microscopy, we show that biofilm aggregates of increasing complexity form ion murine nasal septa following intranasal inoculation. These biofilms were highly distinct from in vitro biofilms, as they were discontiguous and appeared to incorporate nonbacterial components such as intact host cells.

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