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Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice

机译：遗传易感和抗性小鼠的实验性眼弓形虫病

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Genetic factors determining the pathogenesis and course of ocular toxoplasmosis are poorly understood. In this study, we explored the development of experimental ocular pathogenesis in genetically dissimilar mice infected with either the RH strain, the PLK strain, or the immunodominant surface antigen 1 (SAG1 [P30])-deficient mutant of the RH strain of Toxoplasma gondii. At 11 days postinfection, ocular infection of C57BL/6 mice with all of the strains of parasites resulted in severe inflammatory lesions and high numbers of parasites in eye tissue; less severe ocular lesions at earlier histopathology and prolonged survival were observed in this mouse strain infected with either the major surface antigen 1-deficient SAG1?/? strain or the less virulent PLK strain compared with RH infection. In contrast, both BALB/c and CBA/J mice had less severe lesions and low numbers of parasites in their eye tissue, and infection developed into the chronic stage in these mice. There were significantly higher serum levels of gamma interferon and tumor necrosis factor alpha in C57BL/6 mice than in BALB/c and CBA/J mice following ocular infection. These observations confirm earlier reports on systemic immunity to these parasites that the route of Toxoplasma infection markedly influences survival of mice. Our data indicate that genetic factors of the host as well as the parasite strain are critical in determining susceptibility to experimental ocular toxoplasmosis in murine models.
机译：遗传因素确定眼弓形虫病的发病机理和病程知之甚少。在这项研究中，我们探索了被RH株，PLK株或RH株的免疫显性表面抗原1（SAG1 [P30]）缺陷型突变的遗传异种小鼠感染的实验性眼部发病机制的发展。弓形虫。感染后第11天，眼部感染了C57BL / 6小鼠的所有寄生虫菌株均导致严重的炎性病变和眼组织中大量寄生虫。与RH感染相比，在感染了主要表面抗原1缺陷的SAG1 // 株或毒性较低的PLK株感染的该小鼠品系中，在较早的组织病理学中观察到的严重眼部病变较少，并且存活期延长。相反，BALB / c和CBA / J小鼠的眼组织损伤程度较小，寄生虫数量较少，感染已发展为慢性小鼠。眼部感染后，C57BL / 6小鼠的血清γ干扰素和肿瘤坏死因子α水平明显高于BALB / c和CBA / J小鼠。这些观察结果证实了有关这些寄生虫的全身免疫力的早期报道，即弓形虫感染途径明显影响小鼠的存活。我们的数据表明，宿主和寄生虫的遗传因素对于确定鼠模型中实验性眼弓形虫病的敏感性至关重要。

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