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首页> 外文期刊>Infection and immunity >Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp.
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Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp.

机译：MyD88在快速清除复发性博氏疏螺旋体中的双重作用。

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Relapsing fever Borrelia spp. undergo antigenic variation, achieve high levels in blood, and require rapid production of immunoglobulin M (IgM) for clearance. MyD88-deficient mice display defective clearance of many pathogens; however, the IgM response to persistent infection is essentially normal. Therefore, MyD88?/? mice provided a unique opportunity to study the effect of nonantibody, innate host defenses to relapsing fever Borrelia. Infected MyD88?/? mice harbored extremely high levels of B. hermsii in the blood compared to wild-type littermates. In the comparison of MyD88?/? mice and B- and T-cell-deficient scid mice, two features stood out: (i) bacterial numbers in blood were at least 10-fold greater in MyD88?/? mice than scid mice, even though the production of IgM still occurred in MyD88?/? mice; and (ii) many of the MyD88?/? mice were able to exert partial clearance, although with delayed kinetics relative to wild-type mice, a feature not seen in scid mice. Further analysis revealed a delay in the IgM response to lipoproteins expressed by the original inoculum; however, by 6 days of infection antibodies were produced in MyD88?/? mice that could clear spirochetemia in scid mice. While these results indicated that the production of IgM was delayed in MyD88?/? mice, they also point to a second, antibody-independent role for MyD88 signaling in host defense to relapsing fever Borrelia. This second defect was apparent only when antibody levels were limiting.
机译：复发性发烧 Borrelia spp。进行抗原变异，达到血液中的高水平，并需要快速产生免疫球蛋白M（IgM）进行清除。 MyD88缺陷小鼠表现出许多病原体清除缺陷;但是，IgM对持续感染的反应基本上是正常的。因此，MyD88 ？/？小鼠提供了一个独特的机会来研究非抗体，先天宿主防御对狂犬病 Borrelia 的作用。感染了MyD88 ？/？的小鼠带有极高水平的 B。与野生型同窝仔相比血液中的hermsii 。在比较MyD88 ？/？小鼠和B细胞和T细胞缺陷型 scid 小鼠时，有两个特点：（i）血液中的细菌数量至少为尽管IdM的产生仍然发生在MyD88 ？/？小鼠中，但MyD88 ？/？小鼠中的IgM的产生仍比 scid 小鼠高10倍。 （ii）许多MyD88 ？/？小鼠能够发挥部分清除作用，尽管相对于野生型小鼠而言动力学延迟，这在 scid 中是没有的老鼠。进一步的分析表明，IgM对原始接种物表达的脂蛋白的反应有所延迟。然而，经过6天的感染，MyD88 ？/？小鼠中产生了抗体，可以清除 scid 小鼠的螺旋体血病。虽然这些结果表明MyD88 ？/？小鼠的IgM产生被延迟了，但它们还指出了MyD88信号在宿主对复发性发烧 Borrelia < / em>。仅当抗体水平受到限制时，第二个缺陷才明显。

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