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首页> 外文期刊>Infection and immunity >Clearance of Bordetella parapertussis from the Lower Respiratory Tract Requires Humoral and Cellular Immunity
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Clearance of Bordetella parapertussis from the Lower Respiratory Tract Requires Humoral and Cellular Immunity

机译：从下呼吸道清除百日咳博德特氏菌需要体液和细胞免疫

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摘要

Bordetella parapertussis and Bordetella pertussis are closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time and vaccine studies showing that B. pertussis vaccines have little effect on B. parapertussis infection or disease suggest that the protective immunity induced by each does not efficiently cross protect against the other. Although the mechanisms of protective immunity to B. pertussis have been well studied, those of B. parapertussis have not. The present study explores the mechanism by which B. parapertussis is cleared from the lower respiratory tract by anamnestic immunity. Serum antibodies are necessary and sufficient for elimination of this bacterium, and CD4+ T cells, complement, and neutrophils are required for serum antibody-mediated clearance. Mice lacking immunoglobulin A had no defect in their ability to control or clear infection. Interestingly, serum antibody-mediated clearance of B. parapertussis did not require Fc receptors that are required for antibody-mediated clearance of B. pertussis. Together these data support a model for the mechanism of protective immunity to B. parapertussis that is similar but distinct from that of B. pertussis.
机译：百日咳博德特氏菌和百日咳博德特氏菌是密切相关的物种，可引起百日咳，这是一种急性免疫性疾病。它们同时存在于相同的宿主种群中，疫苗研究表明它们是 B。百日咳疫苗对 B的影响很小。副百日咳杆菌感染或疾病表明，彼此诱导的保护性免疫不能有效地相互对抗。虽然对 B具有保护性免疫的机制。百日咳， B百日咳没有。本研究探讨了 B的机制。遗忘症通过记忆消除从下呼吸道清除。血清抗体对于消除这种细菌是必需的，并且足够，而CD4 + T细胞，补体和嗜中性粒细胞则需要通过血清抗体介导的清除。缺乏免疫球蛋白A的小鼠在控制或清除感染方面没有缺陷。有趣的是，血清抗体介导的 B清除。百日咳杆菌不需要抗体介导的 B清除所必需的Fc受体。百日咳。这些数据共同支持了对 B的保护性免疫机制的模型。百日咳与 B相似，但有所不同。百日咳。

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