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首页> 外文期刊>Infection and immunity >LidA, a Translocated Substrate of the Legionella pneumophila Type IV Secretion System, Interferes with the Early Secretory Pathway
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LidA, a Translocated Substrate of the Legionella pneumophila Type IV Secretion System, Interferes with the Early Secretory Pathway

机译：LidA，肺炎军团菌IV型分泌系统的易位底物，干扰早期分泌途径。

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摘要

Legionella pneumophila uses a type IV secretion system to deliver effector molecules into the host cell and establish its replication vacuole. In this study, we investigated the role of LidA, a translocated substrate associated with the surface of the L. pneumophila-containing vacuole. LidA is secreted into the host cell throughout the replication cycle of the bacteria and associates with compartments of the early secretory pathway. When overexpressed in mammalian cells or yeast, LidA interferes with the early secretory pathway, probably via a domain predicted to be rich in coiled-coil structure. Finally, during intracellular replication, the replication vacuoles are in close contact with the endoplasmic reticulum-Golgi intermediate compartment and the Golgi apparatus, suggesting a positive correlation between intracellular growth and association of the vacuole with compartments of the early secretory pathway. We propose that LidA is involved in the recruitment of early secretory vesicles to the L. pneumophila-containing vacuole and that the vacuole associates with the secretory pathway to facilitate this process.
机译：嗜肺军团菌使用IV型分泌系统将效应分子递送到宿主细胞中并建立其复制液泡。在这项研究中，我们研究了LidA（与 L表面相关的易位底物）的作用。含肺炎的液泡LidA在细菌的整个复制周期中都分泌到宿主细胞中，并与早期分泌途径的区室结合。当在哺乳动物细胞或酵母中过表达时，LidA可能会通过预测富含螺旋卷曲结构的结构域干扰早期分泌途径。最后，在细胞内复制期间，复制液泡与内质网-高尔基体中间隔室和高尔基体紧密接触，表明细胞内生长与液泡与早期分泌途径的隔室缔合之间呈正相关。我们建议LidA参与到 L早期分泌囊泡的募集。含有肺炎支原体的液泡，液泡与分泌途径相关联以促进该过程。

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