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首页> 外文期刊>Infection and immunity >Increase in Gamma Interferon-Secreting CD8+, as Well as CD4+, T Cells in Lungs following Aerosol Infection with Mycobacterium tuberculosis
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Increase in Gamma Interferon-Secreting CD8+, as Well as CD4+, T Cells in Lungs following Aerosol Infection with Mycobacterium tuberculosis

机译：气溶胶感染结核分枝杆菌后肺中的γ-干扰素分泌CD8 +和CD4 + T细胞增加

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Although it is well established that CD4+ T cells are required for the protective immune response against tuberculosis (TB), there is some evidence that CD8+ T cells are also involved in the host response to Mycobacterium tuberculosis. There is, however, a paucity of information on the pulmonary CD8+ T-cell response during infection. We therefore have compared the changes in both CD8+ and CD4+ T cells following aerosol infection withM. tuberculosis. There was an observed delay between the peak of infection and the activated T-cell response in the lung. The kinetics of CD8+ and CD4+ T-cell responses in the lung were identical, both peaking at week 8, 4 weeks later than the peak of cellular response in draining lymph nodes. Similar changes in activation/memory phenotypes occurred on the pulmonary CD8+ and CD4+ T cells. Following in vitro restimulation, both subsets synthesized gamma interferon, a cytokine essential for controlling M. tuberculosis infection. Since lung CD8+ T cells are actively expanded during aerosolM. tuberculosis infection, it is important that both CD8+ and CD4+ T cells be targeted in the design of future TB vaccines.
机译：尽管已经确定CD4 + T细胞是抵抗结核病（TB）的保护性免疫反应所必需的，但有一些证据表明CD8 + T细胞也参与其中宿主对结核分枝杆菌的反应。但是，在感染过程中，关于肺CD8 + T细胞反应的信息很少。因此，我们比较了气溶胶感染 M后CD8 + 和CD4 + T细胞的变化。结核病。在感染高峰和肺中激活的T细胞反应之间存在观察到的延迟。肺中CD8 + 和CD4 + T细胞反应的动力学相同，均在第8周达到峰值，比引流淋巴中细胞反应的峰值晚4周。节点。在肺CD8 + 和CD4 + T细胞上，激活/记忆表型也发生了类似的变化。体外再刺激后，这两个子集都合成了γ干扰素，γ干扰素是控制M必需的细胞因子。结核感染。由于肺CD8 + T细胞在气溶胶 M期间活跃地扩增。结核感染，在未来的结核病疫苗设计中，必须同时靶向CD8 + 和CD4 + T细胞。

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