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Effect of 6-Hydroxydopamine on Host Resistance against Listeria monocytogenes Infection

机译：6-羟基多巴胺对宿主抗单核细胞增生性李斯特菌感染的影响

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Recent studies have shown that immunocompetent cells bear receptors of neuropeptides and neurotransmitters and that these ligands play roles in the immune response. In this study, the role of the sympathetic nervous system in host resistance against Listeria monocytogenes infection was investigated in mice pretreated with 6-hydroxydopamine (6-OHDA), which destroys sympathetic nerve termini. The norepinephrine contents of the plasma and spleens were significantly lower in 6-OHDA-treated mice than in vehicle-treated mice. The 50% lethal dose of L. monocytogenes was about 20 times higher for 6-OHDA-treated mice than for vehicle-treated mice. Chemical sympathectomy by 6-OHDA upregulated interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF-α) production in enriched dendritic cell cultures and gamma interferon (IFN-γ) and TNF-α production in spleen cell cultures, whereas chemical sympathectomy had no apparent effect on phagocytic activities, listericidal activities, and nitric oxide production in peritoneal exudate cells and splenic macrophages. Augmentation of host resistance against L. monocytogenesinfection by 6-OHDA was abrogated in IFN-γ?/? or TNF-α?/? mice, suggesting that upregulation of IFN-γ, IL-12, and TNF-α production may be involved in 6-OHDA-mediated augmentation of antilisterial resistance. Furthermore, adoptive transfer of spleen cells immune to L. monocytogenes from 6-OHDA-treated mice resulted in untreated naive recipients that had a high level of resistance against L. monocytogenesinfection. These results suggest that the sympathetic nervous system may modulate host resistance against L. monocytogenesinfection through regulation of production of IFN-γ, IL-12, and TNF-α, which are critical in antilisterial resistance.
机译：最近的研究表明，具有免疫能力的细胞带有神经肽和神经递质的受体，这些配体在免疫反应中发挥作用。在这项研究中，研究了交感神经系统在宿主抵抗单核细胞增生李斯特菌感染中的作用，该小鼠在6-羟基多巴胺（6-OHDA）预处理后会破坏交感神经末端。在6-OHDA处理的小鼠中，血浆和脾脏的去甲肾上腺素含量显着低于媒介物处理的小鼠。 50％的致死剂量 L。用6-OHDA处理的小鼠单核细胞增生要高出用载体处理的小鼠高20倍。通过6-OHDA进行的化学交感神经切除术可在丰富的树突状细胞培养物中上调白细胞介素12（IL-12）和肿瘤坏死因子-α（TNF-α）的产生，在脾细胞培养物中产生γ干扰素（IFN-γ）和TNF-α，而化学交感神经切除术对腹膜渗出液细胞和脾巨噬细胞的吞噬活性，杀菌作用和一氧化氮生成没有明显影响。宿主对 L的抗性增强。 IFN-γ？/？或TNF-α？/？小鼠消除了6-OHDA对单核细胞增生因子的感染，表明IFN-γ的上调， IL-12和TNF-α的产生可能与6-OHDA介导的抗李斯特菌抗性的增强有关。此外，对 L免疫的脾细胞的过继转移。经6-OHDA处理的小鼠中的单核细胞增生导致未处理的幼稚受体对 L的抵抗力很高。单核细胞增生病感染。这些结果表明交感神经系统可能调节宿主对 L的抵抗力。通过调节IFN-γ，IL-12和TNF-α的产生来感染单核细胞增生李斯特菌，这对抗李斯特菌耐药性至关重要。

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