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Feasibility of an HA2 Domain-Based Periodontitis Vaccine

机译:基于HA2域的牙周炎疫苗的可行性

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In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.
机译:在大鼠牙周炎模型中,预先接种齿龈卟啉单胞菌 HA2结合域的血红蛋白可预防疾病。保护作用与诱导的抗HA2免疫球蛋白G(IgG)体液抗体相关。 IgG亚类比率表明,在盐水中施用rHA2时,相对较低的Th2 / Th1驱动响应与保护直接相关。

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