...
首页> 外文期刊>Infection and immunity >Pseudomonas aeruginosa ExoU, a Toxin Transported by the Type III Secretion System, Kills Saccharomyces cerevisiae
【24h】

Pseudomonas aeruginosa ExoU, a Toxin Transported by the Type III Secretion System, Kills Saccharomyces cerevisiae

机译:铜绿假单胞菌ExoU是一种通过III型分泌系统转运的毒素,可以杀死酿酒酵母。

获取原文
           

摘要

ExoU, a protein transported by the type III secretion system of Pseudomonas aeruginosa, is an important cytotoxin, though its mechanism of action is unclear. Here we show that the intracellular expression of ExoU is cytotoxic to Saccharomyces cerevisiae. Furthermore, internal amino- and carboxyl-terminal deletions confirmed that regions of ExoU previously shown to be essential for killing mammalian cells were also required for killing yeast cells. These findings indicate that S. cerevisiae is a useful model organism for the study of ExoU.
机译:ExoU是一种由铜绿假单胞菌(Pseudomonas aeruginosa)的III型分泌系统转运的蛋白质,尽管其作用机理尚不清楚。在这里,我们显示ExoU的细胞内表达对啤酒酵母(Saccharomyces cerevisiae)具有细胞毒性。此外,内部氨基和羧基末端的缺失证实,杀死酵母细胞还需要先前被证明对杀死哺乳动物细胞必不可少的ExoU区域。这些发现表明 S。酿酒酵母是研究ExoU的有用模式生物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号