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首页> 外文期刊>Infection and immunity >In Vivo Lysogenic Conversion of Tox? Streptococcus pyogenes to Tox+ with Lysogenic Streptococci or Free Phage
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In Vivo Lysogenic Conversion of Tox? Streptococcus pyogenes to Tox+ with Lysogenic Streptococci or Free Phage

机译：体内毒素的溶原转化？化脓性链球菌与溶原性链球菌或游离噬菌体转化为Tox +

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摘要

Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eukaryote mediates the efficient induction of toxin-encoding temperate phage and the resultant conversion of Tox? flora to Tox+. Furthermore, we show that both phage induction and subsequent conversion need not happen in the same mammalian host, as host-to-host phage transmission can result in toxigenic conversion within the secondary host. Ultimately, our findings demonstrate that the eukaryotic host serves as an essential component in the phage-mediated evolution of virulence within the microbial population.
机译：温带噬菌体可以在细菌之间转移毒素编码基因，通常导致获得性致病性。然而，关于真核宿主对噬菌体-病原体相互作用的影响知之甚少。使用化脓性链球菌作为模型，我们在体内和体外证明了真核生物介导了毒素诱导的温带噬菌体的有效诱导以及由此产生的Tox ？植物区系为Tox + 。此外，我们显示噬菌体诱导和随后的转化都不需要在同一哺乳动物宿主中发生，因为宿主之间的噬菌体之间的传播可以导致次级宿主内的毒素转化。最终，我们的发现表明，真核宿主是微生物群体内噬菌体介导的毒力进化的重要组成部分。

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