Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

Lan Hu; Thomas E. Hickey

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Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

机译：空肠弯曲杆菌诱导人肠道上皮细胞分泌促炎性趋化因子

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Campylobacter jejuni is a common cause of diarrhea in humans. While the pathogenic mechanisms of C. jejuni are not completely understood, host inflammatory responses are thought to be contributing factors. In this report, C. jejuni 81-176 is shown to up-regulate chemokines essential to inflammatory responses. Growth-related oncogene α (GROα), GROγ, macrophage inflammatory protein 1, monocyte chemoattractant protein 1 (MCP-1), and gamma interferon-inducible protein 10 (γIP-10) mRNA transcription in INT-407 cells was enhanced within 4 h of bacterial exposure. Infection with viable campylobacters was necessary for sustained chemokine transcription and was NF-κB dependent. GROα, γIP-10, and MCP-1 chemokine secretions were confirmed by immunological assays.

机译：空肠弯曲杆菌是人类腹泻的常见原因。而 C的致病机制。空肠尚不完全清楚，宿主的炎症反应被认为是促发因素。在此报告中， C。空肠 81-176被证明可上调炎症反应所必需的趋化因子。 INT-407细胞在4小时内增强了与生长相关的癌基因α（GROα），GROγ，巨噬细胞炎症蛋白1，单核细胞趋化蛋白1（MCP-1）和γ干扰素诱导蛋白10（γIP-10）mRNA的转录。细菌暴露。存活的弯曲杆菌感染对于持续的趋化因子转录是必需的，并且是NF-κB依赖性的。 GROα，γIP-10和MCP-1趋化因子分泌已通过免疫学分析证实。 展开▼

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《Infection and immunity》 |2005年第7期|共4页

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Lan Hu; Thomas E. Hickey;
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中图分类医学免疫学;

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机译：大蒜素抑制肠道上皮细胞自发和TNF-α诱导的促炎细胞因子和趋化因子的分泌。

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机译：弯曲的人肠道上皮细胞中弯曲杆菌诱导的白细胞介素8分泌需要弯曲杆菌分泌的细胞致死性致死性毒素和类似收费的受体介导的NF-κB活化。

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机译：空肠弯曲杆菌/大肠弯曲菌：宿主肠上皮细胞相互作用。

6. Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells [O] . Lan Hu, Thomas E. Hickey 2005

机译：空肠弯曲杆菌诱导人肠道上皮细胞分泌促炎性趋化因子

7. Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells [O] . Hu, Lan, Hickey, Thomas E. 2005

机译：空肠弯曲杆菌诱导人肠道上皮细胞分泌促炎性趋化因子

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机译：空肠弯曲杆菌诱导人肠上皮细胞分泌促炎性趋化因子。

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5. Methods for inducing differentiation of induced pluripotent stem cells into intestinal epithelial cells [P] . 外国专利： JPWO2014132933A1 . 2017-02-02

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Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

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