EspJ Is a Prophage-Carried Type III Effector Protein of Attaching and Effacing Pathogens That Modulates Infection Dynamics

Sivan Dahan; Siouxsie Wiles; Roberto M. La Ragione; Angus Best; Martin J. Woodward; Mark P. Stevens; Robert K. Shaw; Yuwen Chong; Stuart Knutton; Alan Phillips; Gad Frankel

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EspJ Is a Prophage-Carried Type III Effector Protein of Attaching and Effacing Pathogens That Modulates Infection Dynamics

机译：EspJ是一种附着和清除病原体的噬菌体携带的III型效应蛋白，可调节感染动力学。

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Enterohemorrhagic Escherichia coli, enteropathogenic E. coli, and Citrobacter rodentium are highly adapted enteropathogens that successfully colonize their host's gastrointestinal tract via the formation of attaching and effacing (A/E) lesions. These pathogens utilize a type III secretion system (TTSS) apparatus, encoded by the locus of enterocyte effacement, to translocate bacterial effector proteins into epithelial cells. Here, we report the identification of EspJ (E. coli-secreted protein J), a translocated TTSS effector that is carried on the 5′ end of the cryptic prophage CP-933U. Infection of epithelial cells in culture revealed that EspJ is not required for A/E lesion activity in vivo and ex vivo. However, in vivo studies performed with mice demonstrated that EspJ possesses properties that influence the dynamics of clearance of the pathogen from the host's intestinal tract, suggesting a role in host survival and pathogen transmission.

机译：肠出血性大肠杆菌，肠致病性 E。大肠杆菌（Cemtrobacter rodentium）和啮齿类柠檬酸杆菌（Citrobacter rodentium）是高度适应的肠道病原菌，它们通过形成附着和消融（A / E）病变成功地定居在其宿主的胃肠道中。这些病原体利用由肠上皮细胞出现部位编码的III型分泌系统（TTSS）装置将细菌效应蛋白转运到上皮细胞中。在这里，我们报告了EspJ（大肠杆菌分泌蛋白J）的鉴定，EpsJ是在隐性原噬菌体CP-933U 5'端携带的易位TTSS效应子。培养物中上皮细胞的感染表明，EspJ不是体内和离体A / E病变活性所必需的。但是，对小鼠进行的体内研究表明，EspJ具有影响病原体从宿主肠道清除的动力学特性，暗示了宿主存活和病原体传播的作用。 展开▼

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《Infection and immunity》 |2005年第2期|共8页

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Sivan Dahan; Siouxsie Wiles; Roberto M. La Ragione; Angus Best; Martin J. Woodward; Mark P. Stevens; Robert K. Shaw; Yuwen Chong; Stuart Knutton; Alan Phillips; Gad Frankel;
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中图分类医学免疫学;

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1. Characterization of Two Non-Locus of Enterocyte Effacement-Encoded Type III-Translocated Effectors, NleC and NleD, in Attaching and Effacing Pathogens [J] . Olivier Marchés, Siouxsie Wiles, Francis Dziva, Infection and immunity . 2005,第12期

机译：在附着和表面病原体中两个非基因座肠细胞表面编码的III型易位效应子NleC和NleD的表征

2. Quantitative proteomic analysis of type III secretome of enteropathogenic Escherichia coli reveals an expanded effector repertoire for attaching/effacing bacterial pathogens [J] . DengW., YuH.B., DeHoogC.L., Molecular & cellular proteomics: MCP . 2012,第9期

机译：肠病原性大肠杆菌III型分泌组的蛋白质组学定量分析显示，用于附着/清除细菌病原体的效应子范围扩大

3. Role of NleH, a Type III Secreted Effector from Attaching and Effacing Pathogens, in Colonization of the Bovine, Ovine, and Murine Gut [J] . Cordula Hemrajani, Olivier Marches, Siouxsie Wiles, Infection and immunity . 2008,第11期

机译：NleH，一种III型分泌效应物，来自于附着和暴露的病原体，在牛，羊和鼠肠内定植中的作用

4. Characterization of the attaching and effacing mechanism of Escherichia coli in the pig intestine using in vivo, organ culture, and tissue culture infection models [C] . Annual Meeting of the American College of Veterinary Pathologists . 2014

机译：体内，器官培养和组织培养型猪肠中大肠杆菌在猪肠中的附着和抑制机制的表征

5. Signal transduction and cytoskeletal responses in the pathogenesis of attaching and effacing bacterial infection. [D] . Ismaili, Arif. 1998

机译：细菌感染的发生和发展过程中的信号转导和细胞骨架反应。

6. EspJ Is a Prophage-Carried Type III Effector Protein of Attaching and Effacing Pathogens That Modulates Infection Dynamics [O] . Sivan Dahan, Siouxsie Wiles, Roberto M. La Ragione, 2005

机译：EspJ是一种附着和清除病原体的噬菌体携带的III型效应蛋白可调节感染动力学。

7. EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics [O] . Dahan, S, Wiles, S, La Ragione, RM, 2005

机译：EspJ是一种附着和消灭病原体的前噬菌体携带的III型效应蛋白，可调节感染动态

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2. 衣原体III型分泌系统效应蛋白研究进展 [J] . 刘良专 ,吴移谋 . 中国人兽共患病学报 . 2009,第004期

3. 欧洲疯牛病与感染性蛋白子--一种新的病原体所给我们的启示 [J] . 阚百鸣 . 家庭保健 . 2001,第004期

4. 静注免疫球蛋白治疗呼吸道合胞病毒感染与病毒清除效应 [J] . 王晓刚 . 临床儿科杂志 . 1997,第006期

5. 感染性休克大鼠血浆弹性蛋白肽对血流动力学的影响及西维来司钠的干预效应 [J] . 班炜军 ,陈丽 . 中国药物与临床 . 2010,第004期

6. 肠道粘蛋白型O-型糖链调节病原体与肠上皮细胞间作用的研究 [A] . 刘韵 . 2014

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3. New antigen from intracellular pathogens, useful in vaccines against bacterial and viral infections, comprises sequences from extracellular domains of type III membrane proteins, also derived antibodies [P] . 外国专利： FR2850384A1 . 2004-07-30

机译：来自细胞内病原体的新抗原可用于抗细菌和病毒感染的疫苗，包含来自III型膜蛋白细胞外结构域的序列，也包括衍生的抗体

4. BINDING PROTEINS, COMPOSITIONS AND METHODS THEREOF FOR NEUTRALIZATION OF INFECTION OF PATHOGENS HAVING A TYPE III SECRETION SYSTEM [P] . 外国专利： WO2020041394A1 . 2020-02-27

机译：具有III型分泌系统的病原菌感染中和的结合蛋白，组合物及其方法

5. Isolation of proteins of HTLV-III, serological detection of antibodies to HTLV-III in sera of patients with aids and pre-aids conditions, and detection of HTLV-III infection bi/immuno-assays using HTLV-III infection by immuno-assays using HTLV-III and its proteins [P] . 外国专利： IE58321B1 . 1993-09-08

机译：分离HTLV-III蛋白，血清学检测艾滋病和艾滋病患者血清中的HTLV-III抗体，以及使用HTLV-III感染通过免疫测定法检测HTLV-III感染的双向/免疫测定HTLV-III及其蛋白

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EspJ Is a Prophage-Carried Type III Effector Protein of Attaching and Effacing Pathogens That Modulates Infection Dynamics

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