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首页> 外文期刊>Infection and immunity >Pneumococcal Neuraminidases A and B Both Have Essential Roles during Infection of the Respiratory Tract and Sepsis
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Pneumococcal Neuraminidases A and B Both Have Essential Roles during Infection of the Respiratory Tract and Sepsis

机译：肺炎球菌神经氨酸酶A和B在呼吸道感染和败血症感染中均具有重要作用

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We examined the role of the neuraminidases NanA and NanB in colonization and infection in the upper and lower respiratory tract by Streptococcus pneumoniae, as well as the role of these neuraminidases in the onset and development of septicemia following both intranasal and intravenous infection. We demonstrated for the first time using outbred MF1 mouse models of infection that both NanA and NanB were essential for the successful colonization and infection of the upper and lower respiratory tract, respectively, as well as pneumococcal survival in nonmucosal sites, such as the blood. Our studies have shown that in vivo a neuraminidase A mutant is cleared from the nasopharynx, trachea, and lungs within 12 h postinfection, while a neuraminidase B mutant persists but does not increase in either the nasopharynx, trachea, or lungs. We also demonstrated both neuraminidase mutants were unable to cause sepsis following intranasal infections. When administered intravenously, however, both mutants survived initially but were unable to persist in the blood beyond 48 h postinfection and were progressively cleared. The work presented here demonstrates the importance of pneumococcal neuraminidase A and for the first time neuraminidase B in the development of upper and lower respiratory tract infection and sepsis.
机译：我们研究了肺炎链球菌在上呼吸道和下呼吸道中神经氨酸酶NanA和NanB的定植和感染中的作用，以及这些神经氨酸酶在鼻内和鼻后败血病的发生和发展中的作用。和静脉感染。我们首次使用杂种MF1小鼠感染模型证明NanA和NanB分别对成功定植和感染上呼吸道和下呼吸道以及在非粘膜部位（如血液）中的肺炎球菌存活至关重要。我们的研究表明，体内神经氨酸酶A突变体在感染后12小时内从鼻咽，气管和肺中清除，而神经氨酸酶B突变体持续存在，但在鼻咽，气管或肺中均不增加。我们还证明了两种神经氨酸酶突变体在鼻内感染后均不能引起败血症。但是，当静脉内给药时，两个突变体最初都可以存活，但在感染后48小时后仍不能在血液中持续存在，并逐渐清除。此处提出的工作证明了肺炎球菌神经氨酸酶A和神经氨酸酶B在上呼吸道和下呼吸道感染和败血症发展中的重要性。

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