...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Inflammatory Monocytes but Not Neutrophils Are Necessary To Control Infection with Toxoplasma gondii in Mice
【24h】

Inflammatory Monocytes but Not Neutrophils Are Necessary To Control Infection with Toxoplasma gondii in Mice

机译：炎症单核细胞而不是中性粒细胞是控制小鼠弓形虫感染所必需的

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies have suggested that both inflammatory monocytes and neutrophils are important for controlling acute toxoplasmosis in the mouse model. To test the role of these cell types, we used monoclonal antibody (MAb) RB6-8C5 to deplete both subsets of cells or MAb 1A8 to selectively remove neutrophils. RB6-8C5 MAb-treated mice succumbed to oral infection with Toxoplasma gondii, similar to Ccr2?/? mice, which are deficient in monocyte recruitment but have normal neutrophils. In contrast, mice treated with MAb 1A8 controlled parasite replication and survived acute infection. Ccr2?/? mice suffered from acute ileitis and inflammation in the spleen that was associated with a lack of inflammatory monocytes and elevated numbers of neutrophils. RB6-8C5 MAb-treated C57BL/6 mice also suffered from intestinal pathology and splenic damage, although this was less extensive due to the reduced numbers of neutrophils. Neutrophil-depleted infected wild-type mice displayed no pathological changes, compared to untreated infected controls. Collectively, these observations demonstrate the critical role of inflammatory monocytes during the acute infection with the parasite T. gondii and reveal that neutrophils are not protective but rather contribute to the pathology.
机译：先前的研究表明，炎性单核细胞和中性粒细胞均对控制小鼠模型中的急性弓形虫病很重要。为了测试这些细胞类型的作用，我们使用了单克隆抗体（MAb）RB6-8C5来耗尽细胞的两个子集，或者使用MAb 1A8来选择性去除中性粒细胞。 RB6-8C5 MAb治疗的小鼠死于 T 弓形虫的口腔感染，类似于Ccr2 ？/？小鼠，它们缺乏单核细胞招募但中性粒细胞正常。相反，用MAb 1A8处理的小鼠控制了寄生虫复制并在急性感染中幸存下来。 Ccr2 ？/？小鼠患有急性回肠炎和脾脏发炎，其与炎性单核细胞缺乏和嗜中性白细胞增多有关。 RB6-8C5 MAb治疗的C57BL / 6小鼠也遭受肠道病理和脾脏损害，尽管由于中性粒细胞数量减少，其范围较广。与未处理的感染对照组相比，中性粒细胞耗尽的感染野生型小鼠未显示任何病理变化。总的来说，这些观察结果证明了炎性单核细胞在寄生虫 T急性感染过程中的关键作用。并揭示中性粒细胞不是保护性的，而是有助于病理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号