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首页> 外文期刊>Infection and immunity >Inhibition of Chlamydia pneumoniaeReplication in Human Aortic Smooth Muscle Cells by Gamma Interferon-Induced Indoleamine 2,3-Dioxygenase Activity
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Inhibition of Chlamydia pneumoniaeReplication in Human Aortic Smooth Muscle Cells by Gamma Interferon-Induced Indoleamine 2,3-Dioxygenase Activity

机译：γ干扰素诱导的吲哚胺2，3-双加氧酶活性抑制人主动脉平滑肌细胞中肺炎衣原体的复制

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Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been implicated as a potential risk factor in atherosclerosis, possibly because the pathogen can exist in a persistent form similar to that described for Chlamydia trachomatis. The present study investigated whether gamma interferon (IFN-γ) can induce indoleamine 2,3-dioxygenase (IDO) activity in aortic smooth muscle cells, leading to a marked inhibition of C. pneumoniae growth. Our data indicate a stimulation of IDO mRNA expression and dose-dependent enzymatic activity following IFN-γ treatment. IDO-mediated increase in tryptophan catabolism resulted in a dose-dependent marked inhibition of C. pneumoniae replication.
机译：人类呼吸道病原体肺炎衣原体的感染被认为是动脉粥样硬化的潜在危险因素，可能是因为该病原体可以以与沙眼衣原体所述相似的持久形式存在。 em>。本研究调查了γ干扰素（IFN-γ）是否可以诱导主动脉平滑肌细胞中的吲哚胺2,3-二加氧酶（IDO）活性，从而导致对 C的明显抑制。肺炎生长。我们的数据表明，IFN-γ处理后可刺激IDO mRNA表达和剂量依赖性酶活性。 IDO介导的色氨酸分解代谢增加导致 C的剂量依赖性显着抑制。肺炎复制。

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