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首页> 外文期刊>Infection and immunity >Passive Intranasal Monoclonal Antibody Prophylaxis against Murine Pneumocystis carinii Pneumonia
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Passive Intranasal Monoclonal Antibody Prophylaxis against Murine Pneumocystis carinii Pneumonia

机译：鼠鼻卡氏肺孢子虫肺炎的被动鼻内单克隆抗体预防

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Passive antibody immunoprophylaxis is one method used to protect patients against infection if they are unable to mount an adequate active immune response. Topical application of antibody may be effective against infections at mucosal sites. Using a SCID mouse model of Pneumocystis carinii pneumonia, we were able to demonstrate protection against an airborne challenge with P. carinii by intranasal administration of antibody. Immunoglobulin M (IgM) monoclonal antibodies to an epitope shared by mouse and human P. carinii organisms reduced organism numbers by more than 99% under the conditions described. An IgG1 switch variant of one of the IgM monoclonal antibodies was also protective. These experiments provide a model for exploring the utility of this approach in protecting at-risk patients from infection with P. carinii.
机译：被动抗体免疫预防是一种用于保护无法感染患者的主动免疫反应的方法。局部应用抗体可能有效抵抗粘膜部位的感染。使用卡氏肺孢子虫肺炎的SCID小鼠模型，我们能够证明针对 P的空气传播攻击的保护作用。通过鼻内施用抗体来对卡林氏菌。免疫球蛋白M（IgM）单克隆抗体，针对小鼠和人类 P共享的表位。在上述条件下，卡林氏菌减少了99％以上的生物数量。 IgM单克隆抗体之一的IgG1开关变体也具有保护性。这些实验提供了一个模型，用于探索该方法在保护高危患者免于感染 P方面的实用性。卡林氏。

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