Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

Eva Mattsson; Thomas Hartung; Siegfried Morath; Arne Egesten

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Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

机译：来自金黄色葡萄球菌的高度纯化的脂磷壁酸诱导人单核细胞的促凝血活性和组织因子表达，但在全血中却是弱诱导剂：与肽聚糖的比较

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Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.

机译：金黄色葡萄球菌的脂磷壁酸是一种有效的促凝活性，可在分离的单核细胞中促凝，但在全血中却不。相反，葡萄球菌肽聚糖在分离的单核细胞和全血中显示出相同水平的效力，这表明肽聚糖是在涉及革兰氏阳性细菌的严重脓毒症中促凝活性的重要诱导剂。 展开▼

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《Infection and immunity》 |2004年第7期|共5页

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Eva Mattsson; Thomas Hartung; Siegfried Morath; Arne Egesten;
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中图分类医学免疫学;

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1. Peptidoglycan from Staphylococcus aureus Induces Tissue Factor Expression and Procoagulant Activity in Human Monocytes [J] . Eva Mattsson, Heiko Herwald, Lars Bj?rck, Infection and immunity . 2002,第6期

机译：金黄色葡萄球菌的肽聚糖诱导人单核细胞中组织因子的表达和促凝活性

2. Peptidoglycan from Staphylococcus aureus Induces Tissue Factor Expression and Procoagulant Activity in Human Monocytes [J] . Eva Mattsson, Heiko Herwald, Lars Bj?rck, Infection and immunity . 2002,第6期

机译：金黄色葡萄球菌的肽聚糖诱导人单核细胞中组织因子的表达和促凝活性

3. Peptidoglycan and Lipoteichoic Acid from Staphylococcus aureus Induce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood Model [J] . J. E. Wang, P. F. J?rgensen, M. Alml?f, Infection and immunity . 2000,第7期

机译：金黄色葡萄球菌的肽聚糖和脂磷壁酸在人全血模型中诱导T细胞和单核细胞中肿瘤坏死因子α，白介素6（IL-6）和IL-10的产生。

4. High Levels of Human Factor IX Transgene Expression in Mice Increase Blood Procoagulant Activity [C] . M. A. Srour, J. Grupp, Th. Albert, Hemophilia Symposium . 2008

机译：小鼠中高水平的人体因子IX转基因表达增加血液探剂活性

5. Macrophage colony stimulating factor-induced differentiation of human cord blood monocytes into IL-10(high)IL-12(absent) dendritic cells with tolerogenic potential and into a rare population of CD16(+) monocytes. [D] . Li, Geling. 2005

机译：巨噬细胞集落刺激因子诱导人脐带血单核细胞分化为具有耐受原性的IL-10（高）IL-12（缺失）树突状细胞和稀有的CD16（+）单核细胞。

6. Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan [O] . Eva Mattsson, Thomas Hartung, Siegfried Morath, 2004

机译：来自金黄色葡萄球菌的高度纯化的脂磷壁酸诱导人单核细胞的促凝血活性和组织因子表达但在全血中却是弱诱导剂：与肽聚糖的比较

7. Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan [O] . Mattsson, Eva, Hartung, Thomas, Morath, Siegfried, 2004

机译：来自金黄色葡萄球菌的高度纯化的脂磷壁酸诱导人单核细胞的促凝血活性和组织因子表达，但在全血中却是弱诱导剂：与肽聚糖的比较

8. IL-1 and Tumor Necrosis Factor-Alpha Each Up-Regulate Both the Expression of IFN-Gamma Receptors and Enhance IFN-Gamma-Induced HLA-DR Expression on Human Monocytes and a Human Monocytic Cell Line (THP-1) [R] . Krakauer, T., Oppenheim, J. J. 1993

机译：IL-1和肿瘤坏死因子-α各自上调IFN-γ受体的表达并增强人单核细胞和人单核细胞系（THp-1）上IFN-γ诱导的HLa-DR表达

1. PPARɑ激动剂抑制脂多糖诱导的单核细胞组织因子表达和促凝血活性 [J] . 饶绘 ,魏文宁 . 血栓与止血学 . 2007,第006期

1. Antibody recognizing the N-terminal portion of a tissue factor pathway inhibitor capable of inducing procoagulant activity [P] . 外国专利： JP6584397B2 . 2019-10-02

机译：识别能够诱导促凝活性的组织因子途径抑制剂N端部分的抗体

2. Antibody recognizing the N-terminal portion of a tissue factor pathway inhibitor capable of inducing procoagulant activity [P] . 外国专利： JP2016525519A . 2016-08-25

机译：识别能够诱导促凝活性的组织因子途径抑制剂N端部分的抗体

3. Endotoxin-induced thrombosis factor which induces procoagulant activity in endothelial cells [P] . 外国专利： US5227368A . 1993-07-13

机译：内毒素诱导的血栓形成因子，在内皮细胞中诱导促凝活性

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Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

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