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首页> 外文期刊>Infection and immunity >Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes
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Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes

机译：中性粒细胞介导对烟曲霉胚芽管的肺树突状细胞的成熟和流出

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Invasive aspergillosis is a life-threatening complication of neutrophil deficiency or dysfunction. Neutropenia has previously been associated with enhanced influx of CD11b-expressing conventional dendritic cells to the lungs in response to Aspergillus species, but whether neutrophils directly modulate the function of dendritic cells in this infection is not known. We hypothesized that, in the setting of intrapulmonary challenge with Aspergillus, neutrophils promote the maturation and traffic of lung conventional dendritic cells to draining mediastinal lymph nodes. We report that neutropenia results in a marked accumulation of dendritic cells in the lungs of mice challenged with Aspergillus but greatly diminishes their egress to mediastinal lymph nodes independent of neutrophil microbicidal functions. Furthermore, the phenotype of lung dendritic cells was more immature in neutropenic animals than in nonneutropenic mice exposed to the microorganism. Consistent with this, coincubation with neutrophils greatly enhanced the upregulation of costimulatory molecules on dendritic cells exposed to Aspergillus in vitro, a process that was dependent on cell contact and the dendritic cell receptor DC-SIGN. Taken together, our data support an immunomodulatory cross talk between neutrophils and dendritic cells in the context of host response to Aspergillus that promotes the maturation and efflux of lung dendritic cells.
机译：侵袭性曲霉病是中性粒细胞缺乏或功能障碍的危及生命的并发症。嗜中性白血球减少症以前与表达CD11b的常规树突状细胞对曲霉菌种类的反应增强向肺的流入有关，但是尚不知道嗜中性粒细胞在这种感染中是否直接调节树突状细胞的功能。我们假设，在用曲霉菌进行肺内攻击的情况下，中性粒细胞促进了肺常规树突状细胞的成熟和运输，以引流纵隔淋巴结。我们报告中性粒细胞减少症导致小鼠的肺中被曲霉菌挑战的树突状细胞明显积累，但大大减少了它们独立于嗜中性白细胞杀微生物功能的纵隔淋巴结的出口。此外，中性粒细胞减少症动物中肺树突状细胞的表型比暴露于微生物的非中性粒细胞减少症小鼠的表型更不成熟。与此相一致，与嗜中性粒细胞共孵育大大增强了体外暴露于曲霉菌的树突细胞上共刺激分子的上调，该过程依赖于细胞接触和树突细胞受体DC-SIGN。两者合计，我们的数据支持嗜中性粒细胞和树突状细胞之间的免疫调节串扰，在宿主对曲霉的反应中，这促进了肺树突状细胞的成熟和外排。

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