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首页> 外文期刊>Infection and immunity >Development of a Vaccine against Invasive Pneumococcal Disease Based on Combinations of Virulence Proteins of Streptococcus pneumoniae
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Development of a Vaccine against Invasive Pneumococcal Disease Based on Combinations of Virulence Proteins of Streptococcus pneumoniae

机译：基于肺炎链球菌毒力蛋白组合的抗侵袭性肺炎球菌疾病疫苗的开发

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Current global efforts are focused on exploring alternative pneumococcal vaccine strategies, aimed at addressing the shortcomings of existing formulations, without compromising efficacy. One such strategy involves the use of one or more pneumococcal protein antigens common to all serotypes, to provide cheap, non-serotype-dependent protection. In this study, we evaluated the protective efficacy of immunization of mice with PdB (a pneumolysin toxoid), PspA, PspC (CbpA), PhtB, and PhtE in an invasive-disease model. The antigens were administered in alum adjuvant, either alone or in various combinations. Protection against intraperitoneal challenge with virulent type 2 and 6A strains was assessed in two murine strains. Our findings show that in some situations, different individual proteins gave the best (and worst) protection. However, in many cases, a synergistic/additive effect was seen by using multiple proteins even where the individual proteins showed little value by themselves. For instance, the median survival times for mice immunized with combinations of PdB and PspA, PdB and PspC, or PspA and PspC were significantly longer than those for mice immunized with any of the single antigens. To date, the combination of PdB, PspA, and PspC offers the best protection.
机译：当前的全球努力集中于探索替代的肺炎球菌疫苗策略，旨在解决现有配方的缺点，同时又不影响功效。一种这样的策略涉及使用所有血清型共有的一种或多种肺炎球菌蛋白抗原，以提供廉价的，非血清型依赖性的保护。在这项研究中，我们评估了侵入性疾病模型中PdB（一种肺炎球菌溶血素类毒素），PspA，PspC（CbpA），PhtB和PhtE免疫小鼠的保护作用。在明矾佐剂中单独或以多种组合形式施用抗原。在两个鼠类菌株中评估了用强毒的2型和6A型菌株对腹膜内攻击的保护作用。我们的发现表明，在某些情况下，不同的蛋白质可以提供最佳（和最差）保护。但是，在许多情况下，即使单独的蛋白质本身没有什么价值，使用多种蛋白质也会产生协同/加和作用。例如，用PdB和PspA，PdB和PspC或PspA和PspC组合免疫的小鼠的中位生存时间明显长于用任何一种抗原免疫的小鼠。迄今为止，PdB，PspA和PspC的组合提供了最佳保护。

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