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首页> 外文期刊>Infection and immunity >Genetic Polymorphisms of Mannose-Binding Lectin Do Not Influence Placental Malaria but Are Associated with Preterm Deliveries
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Genetic Polymorphisms of Mannose-Binding Lectin Do Not Influence Placental Malaria but Are Associated with Preterm Deliveries

机译：甘露糖结合凝集素的遗传多态性不影响胎盘疟疾，但与早产有关。

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During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta where they induce pathology and increase the risk of low-birth-weight (LBW) babies. The innate immune mediator, mannose-binding lectin (MBL), enhances phagocytosis of pathogens. Since MBL is reported to bind to IE, we hypothesized that it might aid in clearance of IE from the placenta, thereby reducing the risk of LBW babies. To test this hypothesis, molecular genotyping was used to detect polymorphisms at codon 57 (A/C) in exon 1 of MBL2 in 401 pregnant Cameroonian women, with or without placental malaria, who had LBW and normal-weight babies. Polymorphisms in the promoter region at positions ?550 (H/L), ?221 (X/Y), and +4 (P/Q) were also determined, and plasma MBL levels were measured during pregnancy and at delivery. The expected correlation between genotype and plasma MBL levels was confirmed. However, asymptomatic infections were not associated with an increase in MBL levels in the peripheral blood, and MBL levels were similar in the placental and cord blood of women with or without placental malaria at delivery. There was no evidence that MBL levels at delivery were associated with malaria-related poor pregnancy outcomes. Women with the LXPA haplotype, however, were more likely to have LBW babies, but the risk was not related to malaria. These results do not support the hypothesis that MBL aids in the clearance of parasites from the placenta but suggest that Cameroonian women with LXPA are at risk of having LBW babies due to other causes.
机译：怀孕期间，受恶性疟原虫感染的红细胞（IE）隔离在胎盘中，引起疾病并增加了低出生体重（LBW）婴儿的风险。天生的免疫介质甘露糖结合凝集素（MBL）可增强病原体的吞噬作用。由于据报道MBL与IE结合，我们假设它可能有助于从胎盘清除IE，从而降低LBW婴儿的风险。为了验证这一假设，我们采用分子基因分型技术检测了401名患有或未患有胎盘早熟且体重正常的喀麦隆孕妇，在401名喀麦隆孕妇中， MBL2 外显子1的第57外显子（A / C）多态性。体重婴儿。还确定了启动子区域的多态性，在位置550处（H / L），位置221（X / Y）和+4位（P / Q），并在怀孕期间和分娩时测量了血浆MBL水平。确认了基因型和血浆MBL水平之间的预期相关性。但是，无症状感染与外周血MBL水平升高无关，并且在分娩时有或没有胎盘疟疾的妇女的胎盘和脐带血中MBL水平相似。没有证据表明分娩时MBL水平与疟疾相关的不良妊娠结局有关。然而，具有LXPA单倍型的妇女更可能生低体重儿，但风险与疟疾无关。这些结果不支持MBL有助于从胎盘清除寄生虫的假设，但表明喀麦隆LXPA妇女由于其他原因而有生下LBW婴儿的风险。

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