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Leptospira interrogans Binds to Human Cell Surface Receptors Including Proteoglycans

机译：钩端螺旋体与人细胞表面受体结合，包括蛋白聚糖

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Leptospirosis is a global public health problem, primarily in the tropical developing world. The pathogenic mechanisms of the causative agents, several members of the genus Leptospira, have been underinvestigated. The exception to this trend has been the demonstration of the binding of pathogenic leptospires to the extracellular matrix (ECM) and its components. In this work, interactions of Leptospira interrogans bacteria with mammalian cells, rather than the ECM, were examined. The bacteria bound more efficiently to the cells than to the ECM, and a portion of this cell-binding activity was attributable to attachment to glycosaminoglycan (GAG) chains of proteoglycans (PGs). Chondroitin sulfate B PGs appeared to be the primary targets of L. interrogans attachment, while heparan sulfate PGs were much less important. Inhibition of GAG/PG-mediated attachment resulted in partial inhibition of bacterial attachment, suggesting that additional receptors for L. interrogans await identification. GAG binding may participate in the pathogenesis of leptospirosis within the host animal. In addition, because GAGs are expressed on the luminal aspects of epithelial cells in the proximal tubules of the kidneys, this activity may play a role in targeting the bacteria to this critical site. Because GAGs are shed in the urine, GAG binding may also be important for transmission to new hosts through the environment.
机译：钩端螺旋体病是一个全球性的公共卫生问题，主要在热带发展中国家。致病菌， Leptospira 的几个成员的致病机理尚未得到充分研究。这种趋势的一个例外是病原性钩端螺旋体与细胞外基质（ECM）及其组分的结合。在这项工作中，研究了“问号螺旋藻”细菌与哺乳动物细胞而不是ECM的相互作用。细菌与细胞的结合要比与ECM的结合更有效，并且这种细胞结合活性的一部分归因于蛋白聚糖（PGs）与糖胺聚糖（GAG）链的附着。硫酸软骨素B PGs似乎是 L的主要靶标。雌激素依恋，而硫酸乙酰肝素PG的重要性要低得多。 GAG / PG介导的附着的抑制导致细菌附着的部分抑制，表明 L的其他受体。询问者等待确认。 GAG结合可能参与宿主动物内钩端螺旋体病的发病机理。此外，由于GAGs在肾脏近端小管中的上皮细胞管腔表达，因此这种活性可能在将细菌靶向此关键部位方面发挥作用。由于GAGs排在尿液中，因此GAG结合对于通过环境传播给新宿主也可能很重要。

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