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首页> 外文期刊>Infection and immunity >Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells
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Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells

机译：人单核细胞和髓样树突状细胞中细菌抗原对肿瘤坏死受体因子6 /诱饵受体3的选择性诱导释放。

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摘要

Tumor necrosis factor (TNF) receptor 6/decoy receptor 3 (TR6/DcR3) is an antiapoptosis soluble receptor of the TNF family produced by tumor cells. In this study, TR6 expression in human immune cells was investigated. TR6 mRNA and protein were detectable in selected antigen-presenting cells. Monocytes and myeloid-derived dendritic cells (MDC) released the protein exclusively following stimulation of Toll-like receptor 2 (TLR2) and TLR4 by gram-positive and gram-negative bacterial antigens. Plasmacytoid dendritic cells, activated by bacterial antigens via TLR9 or by viral infection, did not produce the protein. Similarly, activated T cells did not release TR6. The release of TR6 by MDC was dependent on the activation of p42/p44 mitogen-activated protein kinases, Src-like protein tyrosine kinases, and phosphatidylinositol 3-kinase, signaling pathways important for MDC maturation and survival. In agreement with the in vitro data, TR6 levels in serum were significantly elevated in patients with bacterial infections. Overall, these data suggest a novel role for TR6 in immune responses to bacteria.
机译：肿瘤坏死因子（TNF）受体6 /诱饵受体3（TR6 / DcR3）是肿瘤细胞产生的TNF家族的抗凋亡可溶性受体。在这项研究中，研究了人类免疫细胞中TR6的表达。在选定的抗原呈递细胞中可检测到TR6 mRNA和蛋白质。单核细胞和髓样来源的树突状细胞（MDC）仅在革兰氏阳性和革兰氏阴性细菌抗原刺激Toll样受体2（TLR2）和TLR4后释放蛋白质。被细菌抗原通过TLR9激活或被病毒感染激活的浆细胞样树突状细胞未产生该蛋白。同样，活化的T细胞也不会释放TR6。 MDC释放TR6取决于p42 / p44丝裂原激活的蛋白激酶，Src样蛋白酪氨酸激酶和磷脂酰肌醇3-激酶的激活，这是MDC成熟和生存的重要信号通路。与体外数据一致，细菌感染患者的血清TR6水平显着升高。总的来说，这些数据表明TR6在细菌的免疫应答中具有新的作用。

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