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首页> 外文期刊>Infection and immunity >Entamoeba histolytica Infection in Children and Protection from Subsequent Amebiasis
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Entamoeba histolytica Infection in Children and Protection from Subsequent Amebiasis

机译：儿童溶血性变形杆菌感染和对随后的阿米巴病的预防

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摘要

The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 years of observation. Annually there were 0.09 episodes/child of E. histolytica-associated diarrhea and 0.03 episodes/child of E. histolytica-associated dysentery. Fecal immunoglobulin A (IgA) anti-parasite Gal/GalNAc lectin carbohydrate recognition domain (anti-CRD) was detected in 91% (183/202) of the children at least once and was associated with a lower incidence of infection and disease. We concluded that amebiasis was a substantial burden on the overall health of the cohort children. Protection from amebiasis was associated with a stool anti-CRD IgA response. The challenge of producing an effective vaccine will be to improve upon naturally acquired immunity, which does not provide absolute protection from reinfection.
机译：在对孟加拉国达卡的一个城市贫民窟的289名学龄前儿童进行的为期4年的前瞻性观察研究中，评估了氨虫病对儿童腹泻病负担的贡献以及从自然感染获得免疫力的程度。完成4年观察的儿童中，至少有80％的人检出了溶血性阿米巴，并且有53％的人再次感染。每年， E儿童有0.09集。溶血性腹泻相关的腹泻和0.03例/儿童。组织溶解性痢疾。粪便免疫球蛋白A（IgA）抗寄生虫Gal / GalNAc凝集素碳水化合物识别结构域（anti-CRD）至少一次在91％（183/202）的儿童中检测到，与感染和疾病的发生率较低相关。我们得出结论，阿米巴病是该队列儿童总体健康的重大负担。防止阿米巴病与粪便抗CRD IgA反应有关。生产有效疫苗的挑战将是提高自然获得的免疫力，而这种免疫力不能提供绝对的防止再感染的保护。

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