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首页> 外文期刊>Infection and immunity >Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis
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Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis

机译：莱姆心脏病中巨噬细胞和多形核白细胞的募集

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Lyme arthritis, caused by the spirochete Borrelia burgdorferi, can be recurrent or prolonged, whereas Lyme carditis is mostly nonrecurring. A prominent difference between arthritis and carditis is the differential representation of phagocytes in these lesions: polymorphonuclear leukocytes (PMN) are more prevalent in the joint, and macrophages predominate in the heart lesion. We have previously shown differential efficiency of B. burgdorferi clearance by PMN and macrophages, and we now investigate whether these functional differences at the cellular level may contribute to the observed differences in organ-specific pathogenesis. When we infected mice lacking the neutrophil chemokine receptor (CXCR2?/? mice) with spirochetes, we detected fewer PMN in joints and less-severe arthritis. Here we have investigated the effects of the absence of the macrophage chemokine receptor CCR2 on the development and resolution of Lyme carditis in resistant (C57BL/6J [B6]) and sensitive (C3H/HeJ [C3H]) strains of mice. In B6 CCR2?/? mice, although inflammation in hearts is mild, we detected an increased burden of B. burgdorferi compared to that in wild-type (WT) mice, suggesting reduced clearance in the absence of macrophages. In contrast, C3H CCR2?/? mice have severe inflammation but a decreased B. burgdorferi burden compared to that in WT C3H mice both at peak disease and during resolution. Histopathologic examination of infected hearts revealed that infected C3H CCR2?/? animals have an increased presence of PMN, suggesting compensatory mechanisms of B. burgdorferi clearance in the hearts of infected C3H CCR2?/? mice. The more efficient clearance of B. burgdorferi from hearts by CCR2?/? versus WT C3H mice suggests a natural defect in the recruitment or function of macrophages in C3H mice, which may contribute to the sensitivity of this strain to B. burgdorferi infection.
机译：由螺旋体 Borrelia burgdorferi 引起的莱姆关节炎可以复发或延长，而莱姆心脏病则大多不复发。关节炎和心脏病之间的显着区别是这些病变中吞噬细胞的差异表示：关节中多形核白细胞（PMN）更为普遍，而心脏病变中则以巨噬细胞为主。我们之前已经显示了 B的差分效率。通过PMN和巨噬细胞清除burgdorferi ，我们现在研究在细胞水平上的这些功能差异是否可能导致观察到的器官特异性发病机制差异。当我们用螺旋体感染缺乏嗜中性粒细胞趋化因子受体的小鼠（CXCR2 ？/？小鼠）时，我们在关节中检出的PMN减少，而关节炎程度更轻。在这里，我们研究了巨噬细胞趋化因子受体CCR2的缺乏对耐药（C57BL / 6J [B6]）和敏感（C3H / HeJ [C3H]）小鼠莱姆性心脏病发展和消退的影响。在B6 CCR2 ？/？小鼠中，尽管心脏发炎较轻，但我们发现 B的负担增加了。 burgdorferi 与野生型（WT）小鼠相比，表明在没有巨噬细胞的情况下清除率降低。相反，C3H CCR2 ？/？小鼠发炎严重，但 B降低。与峰值C3H小鼠在疾病高峰期和解决过程中相比，burgdorferi的负担。感染心脏的组织病理学检查显示，感染的C3H CCR2 ？/？动物的PMN含量增加，提示 B的补偿机制。感染的C3H CCR2 ？/？小鼠心脏中的burgburgeri 清除率。 B的清除效率更高。与野生型C3H小鼠相比，CCR2 ？/？与心脏的burgburgeri 提示C3H小鼠巨噬细胞募集或功能存在天然缺陷，这可能有助于该株对的敏感性> B。 burgdorferi 感染。

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