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首页> 外文期刊>Infection and immunity >Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli
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Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli

机译：B组链球菌的免疫调节影响宿主对由致病性大肠杆菌引起的尿路感染的敏感性。

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摘要

Urinary tract infection (UTI) is most often caused by uropathogenic Escherichia coli (UPEC). UPEC inoculation into the female urinary tract (UT) can occur through physical activities that expose the UT to an inherently polymicrobial periurethral, vaginal, or gastrointestinal flora. We report that a common urogenital inhabitant and opportunistic pathogen, group B Streptococcus (GBS), when present at the time of UPEC exposure, undergoes rapid UPEC-dependent exclusion from the murine urinary tract, yet it influences acute UPEC-host interactions and alters host susceptibility to persistent outcomes of bladder and kidney infection. GBS presence results in increased UPEC titers in the bladder lumen during acute infection and reduced inflammatory responses of murine macrophages to live UPEC or purified lipopolysaccharide (LPS), phenotypes that require GBS mimicry of host sialic acid residues. Taken together, these studies suggest that despite low titers, the presence of GBS at the time of polymicrobial UT exposure may be an overlooked risk factor for chronic pyelonephritis and recurrent UTI in susceptible groups, even if it is outcompeted and thus absent by the time of diagnosis.
机译：尿路感染（UTI）通常是由尿路致病性大肠杆菌（UPEC）引起的。可以通过体育活动将UPEC接种到女性泌尿道（UT）中，这些体育活动会将UTEC暴露于固有的微生物性尿道周围，阴道或胃肠道菌群中。我们报告说，一种常见的泌尿生殖器居民和机会性病原体，B组链球菌（GBS），当在UPEC暴露时存在时，经历了鼠尿道中快速UPEC依赖的排斥，但它影响了急性UPEC-宿主相互作用并改变了宿主对膀胱和肾脏感染持续结果的敏感性。 GBS的存在会导致急性感染期间膀胱内腔中UPEC滴度增加，并且鼠巨噬细胞对活UPEC或纯化的脂多糖（LPS）的炎症反应降低，这些表现型需要宿主唾液酸残基的GBS模仿。综上所述，这些研究表明，尽管滴度很低，但在易感人群中，多菌素UT接触时存在GBS可能是慢性肾盂肾炎和UTI复发的危险因素，即使它已被竞争并因此而在发病时尚无。诊断。

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