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首页> 外文期刊>Infection and immunity >Different Patterns of Toll-Like Receptor 2 Polymorphisms in Populations of Various Ethnic and Geographic Origins
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Different Patterns of Toll-Like Receptor 2 Polymorphisms in Populations of Various Ethnic and Geographic Origins

机译：不同种族和地理来源的人群中类似Toll样受体2多态性的模式

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Upon the invasion of the host by microorganisms, innate immunity is triggered through pathogen recognition by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are the best-studied class of PRRs, and they recognize specific pathogen-associated molecular patterns (PAMPs) from various microorganisms. A large number of studies have shown that genetic variation in TLRs may influence susceptibility to infections. We assessed the genetic variation of TLR2, which encodes one of the most important TLRs, in various populations around the globe and correlated it with changes in the function of the molecule. The three best-known nonsynonymous TLR2 polymorphisms (1892C>A, 2029C>T, and 2258G>A) were assessed in different populations from the main continental masses: Romanians, Vlax-Roma, Dutch (European populations), Han Chinese (East Asia), Dogon, Fulani (Africa), and Trio Indians (America). The 2029C>T polymorphism was absent in both European and non-European populations, with the exception of the Vlax-Roma, suggesting that this polymorphism most likely arose in Indo-Aryan people after migration into South Asia. The 1892C>A polymorphism that was found exclusively in European populations, but not in Asian, African, or American volunteers, probably occurred in proto-Indo-Europeans. Interestingly, 2258G>A was present only in Europeans, including Vlax-Roma, but at a very low frequency. The differential pattern of the TLR2 polymorphisms in various populations may explain some of the differences in susceptibility to infections between these populations.
机译：一旦微生物入侵宿主，先天性免疫就会通过模式识别受体（PRR）识别病原体而触发。 Toll样受体（TLR）是研究最多的PRR类，它们识别来自各种微生物的特定病原体相关分子模式（PAMP）。大量研究表明，TLR中的遗传变异可能会影响对感染的敏感性。我们评估了 TLR2 的遗传变异，该变异编码最重要的TLR之一，遍及全球的各种人群中，并将其与分子功能的变化相关联。在来自主要大陆群的不同人群中评估了三种最著名的同义 TLR2 多态性（1892C> A，2029C> T和2258G> A）：罗马尼亚人，弗拉克斯-罗马人，荷兰人（欧洲人群） ），汉族（东亚），多贡，富拉尼（非洲）和三重印第安人（美国）。除弗拉克斯-罗姆人外，欧洲和非欧洲人口均不存在2029C> T多态性，这表明这种多态性很可能是在迁入南亚后在印度-雅利安人中出现的。 1892C>仅在欧洲人群中发现的多态性，而在亚洲，非洲或美国的志愿者中却没有发现，可能发生在原始印度欧洲人中。有趣的是，仅在包括Vlax-Roma在内的欧洲人中出现了2258G> A，但频率很低。在不同人群中 TLR2 多态性的差异模式可能解释了这些人群之间对感染敏感性的某些差异。

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