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Identification of Early Interactions between Francisella and the Host

机译：鉴定弗朗西斯菌与宿主之间的早期相互作用

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The adaptive immune response to Francisella tularensis is dependent on the route of inoculation. Intradermal inoculation with the F. tularensis live vaccine strain (LVS) results in a robust Th1 response in the lungs, whereas intranasal inoculation produces fewer Th1 cells and instead many Th17 cells. Interestingly, bacterial loads in the lungs are similar early after inoculation by these two routes. We hypothesize that the adaptive immune response is influenced by local events in the lungs, such as the type of cells that are first infected with Francisella. Using fluorescence-activated cell sorting, we identified alveolar macrophages as the first cell type infected in the lungs of mice intranasally inoculated with F. novicida U112, LVS, or F. tularensis Schu S4. Following bacterial dissemination from the skin to the lung, interstitial macrophages or neutrophils are infected. Overall, we identified the early interactions between Francisella and the host following two different routes of inoculation.
机译：对土拉弗朗西斯菌的适应性免疫反应取决于接种途径。土库曼弗雷伯氏菌活疫苗株（LVS）的皮内接种会在肺部产生强烈的Th1反应，而鼻内接种会产生较少的Th1细胞，而是产生许多Th17细胞。有趣的是，通过这两种途径接种后，肺中的细菌负荷相似。我们假设适应性免疫反应受肺部局部事件的影响，例如首先感染弗朗西斯菌的细胞类型。使用荧光激活的细胞分选，我们将肺泡巨噬细胞确定为鼻内接种了新葡萄球菌U112，LVS或tularensis Schu S4的小鼠肺部感染的第一类细胞。在细菌从皮肤传播到肺部之后，间质巨噬细胞或中性粒细胞被感染。总的来说，我们确定了弗朗西斯菌与宿主之间通过两种不同的接种途径的早期相互作用。

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