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首页> 外文期刊>Infection and immunity >Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children
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Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

机译：白细胞介素10（IL-10）基因多态性与IL-10产生和儿童临床疟疾相关。

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The role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in 240 children and their mothers from a longitudinal prospective cohort and assessed the IL-10 production by maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs). Clinical episodes of Plasmodium falciparum malaria in the children were documented until the second year of life. The polymorphism IL-10 A-1082G (GCC haplotype of three SNPs in IL-10) in children was associated with IL-10 production levels by CBMC cultured with P. falciparum-infected erythrocytes (P = 0.043), with the G allele linked to low IL-10 production capacity. The G allele in children was also significantly associated with a decreased risk for clinical malaria infection in their second year of life (P = 0.016). Furthermore, IL-10 levels measured in maternal PBMCs cultured with infected erythrocytes were associated with increased risk of malaria infection in young children (P < 0.001). In conclusion, IL-10 polymorphisms and IL-10 production capacity were associated with clinical malaria infections in young children. High IL-10 production capacity inherited from parents may diminish immunological protection against P. falciparum infection, thereby being a risk for increased malaria morbidity.
机译：白细胞介素10（IL-10）在疟疾中的作用仍然很差。这项研究的目的是调查（i）IL-10基因的遗传变异是否会影响IL-10的产生，以及（ii）IL-10的产生以及儿童中IL-10基因的基因型和单倍型及其母亲与幼儿临床疟疾的发病率有关。我们对来自纵向前瞻性队列研究的240名儿童及其母亲的三个IL-10单核苷酸多态性进行了基因分型，并评估了母体外周血单核细胞（PBMC）和脐带血单核细胞（CBMC）的IL-10产生。记录到儿童恶性疟原虫疟疾的临床发作直至生命的第二年。儿童多态性IL-10 A-1082G（IL-10中三个SNP的GCC单倍型）与通过恶性疟原虫感染的红细胞（P = 0.043）培养的CBMC产生的IL-10产生水平相关，P等位基因连锁降低IL-10的生产能力。儿童的G等位基因也与他们生命的第二年减少临床疟疾感染的风险显着相关（P = 0.016）。此外，在感染了红细胞的母体PBMC中测得的IL-10水平与幼儿感染疟疾的风险增加有关（P <0.001）。总之，IL-10多态性和IL-10生产能力与幼儿临床疟疾感染有关。父母遗传的高IL-10生产能力可能削弱针对恶性疟原虫感染的免疫学保护，从而有增加疟疾发病率的风险。

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