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首页> 外文期刊>Infection and immunity >A Stenotrophomonas maltophilia Strain Evades a Major Caenorhabditis elegans Defense Pathway
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A Stenotrophomonas maltophilia Strain Evades a Major Caenorhabditis elegans Defense Pathway

机译：嗜麦芽窄食单胞菌菌株逃避主要秀丽隐杆线虫防御途径。

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Stenotrophomonas maltophilia is a ubiquitous bacterium and an emerging nosocomial pathogen. This bacterium is resistant to many antibiotics, associated with a number of infections, and a significant health risk, especially for immunocompromised patients. Given that Caenorhabditis elegans shares many conserved genetic pathways and pathway components with higher organisms, the study of its interaction with bacterial pathogens has biomedical implications. S. maltophilia has been isolated in association with nematodes from grassland soils, and it is likely that C. elegans encounters this bacterium in nature. We found that a local S. maltophilia isolate, JCMS, is more virulent than the other S. maltophilia isolates (R551-3 and K279a) tested. JCMS virulence correlates with intestinal distension and bacterial accumulation and requires the bacteria to be alive. Many of the conserved innate immune pathways that serve to protect C. elegans from various pathogenic bacteria also play a role in combating S. maltophilia JCMS. However, S. maltophilia JCMS is virulent to normally pathogen-resistant DAF-2/16 insulin-like signaling pathway mutants. Furthermore, several insulin-like signaling effector genes were not significantly differentially expressed between S. maltophilia JCMS and avirulent bacteria (Escherichia coli OP50). Taken together, these findings suggest that S. maltophilia JCMS evades the pathogen resistance conferred by the loss of DAF-2/16 pathway components. In summary, we have discovered a novel host-pathogen interaction between C. elegans and S. maltophilia and established a new animal model with which to study the mode of action of this emerging nosocomial pathogen.
机译：嗜麦芽窄食单胞菌是一种普遍存在的细菌，是一种新兴的医院病原体。该细菌对许多抗生素具有抵抗力，与许多感染相关，并且对健康特别是免疫功能低下的患者有很大的健康风险。鉴于秀丽隐杆线虫与高级生物共有许多保守的遗传途径和途径组成，因此研究其与细菌病原体的相互作用具有生物医学意义。已经从草原土壤中与线虫相关联地分离出嗜麦链球菌，并且秀丽隐杆线虫很可能在自然界中遇到了这种细菌。我们发现，本地沙门氏菌的分离株，JCMS，比其他沙门氏菌的分离株（R551-3和K279a）更具毒性。 JCMS毒力与肠道扩张和细菌积聚相关，需要细菌存活。许多保守的先天免疫途径可用来保护秀丽隐杆线虫免受各种病原菌的侵害，在对抗嗜麦芽链球菌JCMS中也发挥着作用。但是，嗜麦芽孢杆菌JCMS对通常抵抗病原体的DAF-2 / 16胰岛素样信号通路突变体具有毒性。此外，在嗜麦芽孢杆菌JCMS和无毒细菌（大肠杆菌OP50）之间，没有几个胰岛素样信号转导效应子基因显着差异表达。综上所述，这些发现表明，嗜麦芽孢杆菌JCMS规避了DAF-2 / 16途径组分的损失所赋予的病原体抗性。总而言之，我们发现了秀丽隐杆线虫和嗜麦芽窄食单胞菌之间新型的宿主-病原体相互作用，并建立了新的动物模型来研究这种新兴的医院病原体的作用方式。

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