...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Staphlyococcus aureus Phenol-Soluble Modulins Stimulate the Release of Proinflammatory Cytokines from Keratinocytes and Are Required for Induction of Skin Inflammation
【24h】

Staphlyococcus aureus Phenol-Soluble Modulins Stimulate the Release of Proinflammatory Cytokines from Keratinocytes and Are Required for Induction of Skin Inflammation

机译：金黄色葡萄球菌苯酚可溶的Modulins刺激角质形成细胞释放促炎细胞因子，是诱导皮肤炎症所必需的

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Staphylococcus aureus is a human commensal that colonizes the skin. While it is normally innocuous, it has strong associations with atopic dermatitis pathogenesis and has become the leading cause of skin and soft tissue infections in the United States. The factors that dictate the role of S. aureus in disease are still being determined. In this work, we utilized primary keratinocyte culture and an epidermal murine colonization model to investigate the role of S. aureus phenol-soluble modulins (PSMs) in proinflammatory cytokine release and inflammation induction. We demonstrated that many species of Staphylococcus are capable of causing release of interleukin 18 (IL-18) from keratinocytes and that S. aureus PSMs are necessary and sufficient to stimulate IL-18 release from keratinocytes independently of caspase 1. Further, after 7 days of epicutaneous exposure to wild-type S. aureus, but not S. aureus Δpsm, we saw dramatic changes in gross pathology, as well as systemic release of proinflammatory cytokines. This work demonstrates the importance of PSM peptides in S. aureus-mediated inflammatory cytokine release from keratinocytes in vitro and in vivo and further implicates PSMs as important contributors to pathogenesis.
机译：金黄色葡萄球菌是人类定居在皮肤上的一种表彰。虽然它通常是无毒的，但它与特应性皮炎的发病机理密切相关，并已成为美国皮肤和软组织感染的主要原因。决定金黄色葡萄球菌在疾病中的作用的因素仍在确定中。在这项工作中，我们利用原发性角质形成细胞培养和表皮小鼠定植模型来研究金黄色葡萄球菌酚溶性调节蛋白（PSM）在促炎性细胞因子释放和炎症诱导中的作用。我们证明了许多葡萄球菌能够引起白细胞介素18（IL-18）从角质形成细胞的释放，而金黄色葡萄球菌PSM是必需且足以刺激caspase 1独立于角质形成细胞的IL-18释放。表皮暴露于野生型金黄色葡萄球菌而不是金黄色葡萄球菌Δpsm，我们发现总体病理学发生了巨大变化，并且促炎性细胞因子的系统释放。这项工作证明了PSM肽在体外和体内金黄色葡萄球菌介导的角化细胞释放的炎性细胞因子释放中的重要性，并进一步暗示PSM是发病机理的重要贡献者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号