...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Variation in the Susceptibility of Drosophila to Different Entomopathogenic Nematodes
【24h】

Variation in the Susceptibility of Drosophila to Different Entomopathogenic Nematodes

机译：果蝇对不同病原线虫的易感性变化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Entomopathogenic nematodes (EPNs) in the genera Heterorhabditis and Steinernema are lethal parasites of insects that are of interest as models for understanding parasite-host interactions and as biocontrol agents for insect pests. EPNs harbor a bacterial endosymbiont in their gut that assists in insect killing. EPNs are capable of infecting and killing a wide range of insects, yet how the nematodes and their bacterial endosymbionts interact with the insect immune system is poorly understood. Here, we develop a versatile model system for understanding the insect immune response to parasitic nematode infection that consists of seven species of EPNs as model parasites and five species of Drosophila fruit flies as model hosts. We show that the EPN Steinernema carpocapsae, which is widely used for insect control, is capable of infecting and killing D. melanogaster larvae. S. carpocapsae is associated with the bacterium Xenorhabdus nematophila, and we show that X. nematophila induces expression of a subset of antimicrobial peptide genes and suppresses the melanization response to the nematode. We further show that EPNs vary in their virulence toward D. melanogaster and that Drosophila species vary in their susceptibilities to EPN infection. Differences in virulence among different EPN-host combinations result from differences in both rates of infection and rates of postinfection survival. Our results establish a powerful model system for understanding mechanisms of host-parasite interactions and the insect immune response to parasitic nematode infection.
机译：异虫眼和Steinernema属中的致病性线虫（EPN）是昆虫的致死性寄生虫，作为理解寄生虫-宿主相互作用的模型和作为害虫的生物防治剂而受到关注。 EPN在其肠道中带有细菌共生共生体，有助于杀死昆虫。 EPNs能够感染和杀死各种昆虫，但是对于线虫及其细菌内共生体如何与昆虫免疫系统相互作用却知之甚少。在这里，我们开发了一种通用的模型系统，用于了解昆虫对寄生线虫感染的免疫反应，该系统由7种EPNs作为模型寄生虫和5种果蝇果蝇作为模型宿主。我们表明，EPN Steinernema carpocapsae，广泛用于昆虫防治，能够感染和杀死D. melanogaster幼虫。 Carpocapsae与细菌线虫Xenorhabdus关联，并且我们显示线虫X. nematophila诱导表达抗菌肽基因的一个子集并抑制对线虫的黑色素化反应。我们进一步表明，EPN对D. melanogaster的毒力不同，而果蝇对EPN感染的敏感性也不同。不同的EPN-宿主组合之间毒力的差异是由于感染率和感染后存活率的差异所致。我们的结果建立了一个强大的模型系统，用于了解宿主-寄生虫相互作用的机制以及昆虫对寄生线虫感染的免疫反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号