• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Development and Characterization of a Long-Term Murine Model of Streptococcus pneumoniae Infection of the Lower Airways
【24h】

Development and Characterization of a Long-Term Murine Model of Streptococcus pneumoniae Infection of the Lower Airways

机译：下呼吸道肺炎链球菌感染的长期小鼠模型的开发和表征

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic obstructive pulmonary disease (COPD) is characterized by long periods of stable symptoms, but exacerbations occur, which result in a permanent worsening of symptoms. Previous studies have shown a link between bacterial colonization of the lower airways of COPD sufferers and an increase in exacerbation frequency. One of the most frequent bacterial colonizers is Streptococcus pneumoniae. To mimic this aspect of COPD, a murine model of low-level pneumococcal colonization in the lung has been developed, in which S. pneumoniae persisted in the lungs for at least 28 days. From day 14 postinfection, bacterial numbers remained constant until at least 28 days postinfection, and animals showed no outward signs of disease. The bacterial presence correlated with a low-level inflammatory response that was localized to small foci across the left and inferior lobes of the lung. The cellular response was predominantly monocytic, and focal fibroplasia was observed at the airway transitional zones. Physiological changes in the lungs were investigated with a Forced Maneuvers system. This new model provides a means of study of a long-term pulmonary infection with a human pathogen in a rodent system. This is an excellent tool for the development of future models that mimic complex respiratory diseases such as COPD and asthma.
机译：慢性阻塞性肺疾病（COPD）的特征是长期稳定的症状，但会加重症状，从而导致症状永久恶化。先前的研究表明，COPD患者下呼吸道的细菌定植与病情加重之间存在联系。最常见的细菌定居者之一是肺炎链球菌。为了模仿COPD的这一方面，已经开发了一种在肺中低水平肺炎球菌定殖的小鼠模型，其中肺炎链球菌在肺中持续至少28天。从感染后第14天开始，细菌数量一直保持恒定，直到感染后至少28天，并且动物没有显示出疾病的外在迹象。细菌的存在与低水平的炎症反应有关，该炎症反应位于肺左叶和下叶的小病灶上。细胞反应主要是单核细胞，并在气道过渡区观察到局灶性纤维化。用强制操纵系统研究了肺部的生理变化。该新模型提供了一种研究啮齿动物系统中长期感染人类病原体的肺脏的方法。这是开发将来模拟复杂呼吸系统疾病（例如COPD和哮喘）的模型的绝佳工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号