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首页> 外文期刊>Infection and immunity >Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment
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Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment

机译：甾体类圆线虫感染和治疗后改变的全身细胞因子谱

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Strongyloides stercoralis is a soil-transmitted helminth organism that infects ～50 to 100 million people worldwide. Despite its widespread prevalence, very little is known about the immune response that characterizes human S. stercoralis infection. To study the systemic cytokine profile characteristic of Strongyloides infection, we measured the circulating levels of a large panel of pro- and anti-inflammatory cytokines in asymptomatic, infected individuals (n = 32) and compared them to those in uninfected, controls (n = 24). Infected individuals exhibited significantly lower circulating levels of proinflammatory cytokines (gamma interferon [IFN-γ], tumor necrosis factor alpha [TNF-α], and interleukin-1β [IL-1β]) and significantly higher levels of anti-inflammatory cytokines (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and transforming growth factor β [TGF-β]). Moreover, treatment of Strongyloides infection resulted in a significant reversal of the cytokine profile, with increased levels of proinflammatory (IFN-γ, TNF-α, IL-2, IL-17A, IL-17F, IL-22, IL-23, and IL-1β) and decreased levels of anti-inflammatory (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and TGF-β) cytokines following treatment. Thus, S. stercoralis infection is characterized by alterations in the levels of systemic cytokines, reflecting major alterations in the underlying immune response to this chronic helminth infection.
机译：硬皮实蝇（Strongyloides stercoralis）是一种土壤传播的蠕虫生物，在全世界感染约50至1亿人。尽管其广泛流行，但对表征人固醇链球菌感染的免疫反应知之甚少。为了研究强茎线虫感染的系统细胞因子谱特征，我们测量了无症状感染个体（ n = 32）中大量促炎和抗炎细胞因子的循环水平，并将其与那些进行比较。在未感染的对照中（ n = 24）。受感染的个体表现出明显较低的促炎细胞因子循环水平（γ干扰素[IFN-γ]，肿瘤坏死因子α[TNF-α]和白介素1β[IL-1β]）和显着较高水平的抗炎细胞因子（IL -4，IL-5，IL-9，IL-10，IL-13，IL-27，IL-37和转化生长因子β[TGF-β]）。此外，治疗圆线虫感染会导致细胞因子谱的显着逆转，促炎水平升高（IFN-γ，TNF-α，IL-2，IL-17A，IL-17F，IL-22，IL-23，和IL-1β）和抗炎药（IL-4，IL-5，IL-9，IL-10，IL-13，IL-27，IL-37和TGF-β）细胞因子水平降低。因此，固醇链球菌感染的特征在于全身细胞因子水平的改变，反映了对该慢性蠕虫感染的潜在免疫反应的重大改变。

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