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首页> 外文期刊>International Journal of Engineering Research and Applications >Synthesis and Characterization of Microporous Cryogel Matrices with Anti-inflammatory Effect
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Synthesis and Characterization of Microporous Cryogel Matrices with Anti-inflammatory Effect

机译：具有抗炎作用的微孔冷冻凝胶基质的合成与表征

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The aims of this paper are the synthesis, the physicochemical characterization and in vitro analysis of microporous cryogels matrices. Polyvinyl-alcohol (PVA) is a non-toxic linear polymer, highly soluble in water, resistant to organic solvents and frequently used in medical applications. ketoprofen is a non-steroidal anti-inflammatory drug used in various topical and oral pharmaceutical forms. Cryogelation is a technology that makes interconnected pore structure in moderately frozen condition after four freeze/thaw cycles. The morphology of the cryogels, the interaction between the PVA macromolecular chains and ketoprofen has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic medium have been monitored in order to establish the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements and the concentration of ketoprofen released by spectrophotometry. The new microporous cryogel matrices shows good physical, morphological and drug release properties.....
机译：本文的目的是微孔冷冻凝胶基质的合成，理化表征和体外分析。聚乙烯醇（PVA）是一种无毒的线型聚合物，高度溶于水，耐有机溶剂，经常用于医疗应用。酮洛芬是一种非甾体抗炎药，以各种局部和口服药物形式使用。冷冻凝胶化是一种技术，它在四个冷冻/融化循环后，在中等程度的冷冻条件下使相互连接的孔结构成为可能。已通过扫描电子显微镜研究了冷冻凝胶的形态，PVA大分子链与酮洛芬之间的相互作用。为了建立亲水性，已经监测了在生理介质中溶胀的凝胶。通过动态力学测量和分光光度法释放的酮洛芬浓度研究了晶状体的机械性能。新的微孔冷冻凝胶基质显示出良好的物理，形态和药物释放特性.....

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