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HIV viral suppression in Oman: Encouraging progress toward achieving the United Nations ‘third 90’

机译:阿曼的HIV病毒抑制:鼓励在实现联合国“第三90号”目标方面取得进展

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Objective To assess the impact of capacity-building interventions introduced by the Oman National AIDS Programme on the quality of HIV care in the country. Methods HIV viral load (VL) suppression and loss to follow-up (LTFU) rates were calculated for the period before (in December 2015; n ? = ? 1098) and after (in June 2017; n ? = ? 1185) the introduction of the interventions: training, support, and care pathway development. Three HIV VL cuts-offs at last measurement in the year of interest were used to define VL suppression. Results In the intention-to-treat (ITT) analysis, rates of VL 200 copies/ml and 1000 copies/ml increased from 51.9% in 2015 to 65.5% in 2017 (relative risk (RR) 1.26, 95% confidence interval (CI) 1.17–1.36) and from 58.1% in 2015 to 70.9% in 2017 (RR 1.22, 95% CI 1.14–1.30), respectively; p ? ? 0.0001 for both. Similarly, in the on-treatment analysis, rates of VL 200 copies/ml and 1000 ? copies/ml increased from 64.2% in 2015 to 76.9% in 2017 (RR 1.20, 95% CI 1.12–1.28) and from 71.9% in 2015 to 83.2% in 2017 (RR 1.16, 95% CI 1.10–1.22), respectively. Fewer patients were LTFU in 2017 than in 2015 (14.7% (157/1061) vs. 19.2% (188/981); RR 0.77, 95% CI 0.64–0.94). Conclusions Achieving the UNAIDS target of 90% of HIV patients on treatment having VL suppression by 2020 is feasible in Oman.
机译:目的评估阿曼国家艾滋病规划署采取的能力建设干预措施对该国艾滋病毒护理质量的影响。方法在引入前(2015年12月; n = 1098)和之后(2017年6月; n = 1185)计算HIV病毒载量(VL)抑制和随访失访(LTFU)率。干预措施:培训,支持和护理途径发展。在相关年份的最后一次测量中,三个HIV VL截止值用于定义VL抑制。结果在意向性治疗(ITT)分析中,VL <200拷贝/毫升和<1000拷贝/毫升的VL率从2015年的51.9%增加到2017年的65.5%(相对风险(RR)1.26、95%置信区间) (CI)1.17–1.36)和分别从2015年的58.1%到2017年的70.9%(RR 1.22、95%CI 1.14-1.30); ? <?两者均为0.0001。类似地,在治疗分析中,VL的比率<200拷贝/ ml和<1000?每毫升拷贝数从2015年的64.2%增加到2017年的76.9%(RR 1.20,95%CI 1.12-1.28)和从2015年的71.9%增至2017年的83.2%(RR 1.16,95%CI 1.10-1.22)。与2015年相比,2017年使用LTFU的患者更少(14.7%(157/1061)vs. 19.2%(188/981); RR 0.77,95%CI 0.64-0.94)。结论在阿曼实现到2020年90%的HIV患者接受VL抑制治疗的UNAIDS目标是可行的。

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